Conceptual models of information systems emerge as the result of cooperation among diierent user groups. There are however few research eeorts focused on providing collaboration support for this activity. This thesis aims at suggesting methods and tools originating from CSCW research eld for supporting collaborative conceptual modeling. A framework for studying collaboration support for user pa...

We give a short introduction into polyelectrolytes and show some of the problems of modeling charged polymer systems. We concentrate on two model systems. The first one consists of flexible polyelectrolytes exposed to a poor solvent. These polymers show interesting conformational behavior. We will discuss them and hint to the difficulties of observing conformational transitions in light scatter...

paper provides a nontechnicul introduction to queuing network concepts, a short introduction to results of research into analytical modeling methodology, and u set of simple but typical examples that illustrute the upplication of that methodology to problems of computer perfbrmunce. The objectives of this paper are to introduce concepts of the theory of queuing networks, to describe an APL prog...

Interim Reports on work of the International Institute for Applied Systems Analysis receive only limited review. Views or opinions expressed herein do not necessarily represent those of the Institute, its National Member Organizations, or other organizations supporting the work. Abstract Modeling earthquakes plays an important role in investigation of different aspects of seismic risk. The pape...

A number of large research initiatives (IUPS Physiome, EuroPhysiome, SimBio, etc.) aim to develop computer models of human physiology that span multiple dimensional and temporal scales. The Living Human Project (LHP) is a three-year international collaboration that will develop such multiscale predictive models for the musculoskeletal apparatus. The aim of this paper is to update the reader on ...

During the design of new technical systems, their manufacturing tolerances (i.e. system parameter uncertainties) should be determined basically by working requirements of the system and technological possibilities of the manufacturers. Therefore the determination of manufacturing tolerances can be a very important and difficult task. It is possible that system output parameter values are inadeq...

performance analysis of distributed applications and protocols. An emulation scenario consists of a network topology, link parameters, and dynamic change models. In order to set up a scenario automatically, it has to be modeled in an appropriate description language. In this paper, we analyze the requirements for an emulation scenario description language and propose a possible solution.

The recent development of models of atrial cellular dynamics and of realistic atrial anatomic structures has enabled modeling and computer simulation to become important investigative tools in the analysis of atrial arrhythmias. The cell model includes membrane potential, transmembrane ionic currents and ion concentrations. The tissue model describes the overall geometric structure of the tissu...

The occlusion of a blood vessel in the brain causes an ischemic stroke. Current treatment relies restoration of blood flow within 3 hours. Substantial research has focused on neuroprotection to spare compromised neural tissue and extend the treatment time window. Despite success with animal models and extensive associated clinical testing, there are still no therapies of this kind. Ischemic str...