Determining the rate at which men develop genital warts after infection with alpha genus human papillomavirus (HPV) types will provide important information for the design of prevention strategies. We conducted a cohort study of 18-21-year-old men who underwent triannual genital examinations. The 24-month cumulative genital wart incidence was 57.9% (95% confidence interval [CI], 38.1%-79.1%) am...

Abstract Introduction Associations of sleep duration with health outcomes could differ depending on whether is restorative. Age-related changes in the relationship between need and opportunity also influence these associations. Methods Using data from 5804 participants Sleep Heart Health Study, a multicenter population-based prospective cohort study, we examined longitudinal association feeling...

The spindle checkpoint delays exit from mitosis in cells with spindle defects. In this paper, we show that Chk2 is required to delay anaphase onset when microtubules are completely depolymerized but not in the presence of relatively few unattached kinetochores. Mitotic exit in Chk2-deficient cells correlates with reduced levels of Mps1 protein and increased Cdk1-tyrosine 15 inhibitory phosphory...

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An antifungal antibiotic (S) 2-amino-4-oxo-5-hydroxypentanoic acid, inhibited the biosynthesis of the aspartate family of amino acids (methionine, isoleucine and threonine) followed by the inhibition of protein biosynthesis in Saccharomyces cerevisiae. This inhibition was effected by impeding the biosynthesis of their common intermediate precursor, homoserine. The inhibition of biosynthesis of ...

BACKGROUND GL331 is a topoisomerase II inhibitor and, in this study, the effects of GL331 upon rat C6 glioma cells were investigated. MATERIALS AND METHODS The glioma cells were treated with GL331, then a cytotoxicity assay was done to evaluate the cytotoxic effects of GL331 and flow-activated cell sorter analysis was performed to analyze the cellular apoptosis and cell cycle distribution of ...

Yuma Kinoshita, 2, ∗ Ryo Namiki, 2 Takashi Yamamoto, 2 Masato Koashi, 2, 3 and Nobuyuki Imoto 2, 3 Division of Materials Physics, Department of Materials Engineering Science, Graduate school of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan CREST Reserch Team for Photonic Quantum Information, 4-1-8 Honmachi, Kawaguchi, Saitama 331-0012, Japan SORST Res...

We recently proposed a structural model for the Si!331"-!12!1" surface reconstruction containing silicon pentamers and adatoms as elementary structural building blocks. Using first-principles density functional theory we here investigate the stability of a variety of adatom configurations and determine the lowest-energy configuration. We also present a detailed comparison of the energetics betw...

http://heart.bmj.com/content/96/5/331.full.html Updated information and services can be found at: These include: References http://heart.bmj.com/content/96/5/331.full.html#ref-list-1 This article cites 25 articles, 18 of which can be accessed free at: service Email alerting box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up ...

1Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil 2Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP/EPM), 04023-062 São Paulo, SP, Brazil 3Emory Vaccine Center and Department of Microbiology and Immunology, Emory University Sc...