Introduction Postnatal cytomegalovirus (CMV) infection of immunocompetent hosts is usually inapparent but typically results in lifelong latency. Congenital CMV infections as well patients with immunodeficiencies have been linked to major cerebellar pathology. Patients severe mental illness repeatedly found smaller cerebellum, and they may be particularly susceptible infections. Finally, both an...

Congenital CMV is the leading cause of congenital infections in newborns worldwide and can lead to significant morbidity, mortality, or long-term consequences. Purpose — demonstrate results screening for cytomegalovirus infection pregnant women children first months life illustrate a clinical case severe difficulties selecting specific therapy. Materials methods. The article presents retrospect...

AIM To time the onset of cytomegalovirus (CMV) infection in patients (n = 39) with CMV associated neonatal cholestasis by analysing CMV DNA on Guthrie cards sampled at 3 days of age. METHODS CMV infection was diagnosed by serology/urine isolation or by CMV DNA detection (polymerase chain reaction) in liver biopsy specimens. In order to time the infection dry blood filter paper discs were punc...

Cytomegalovirus (CMV) reinfections have been associated with damaging congenital infection and adverse outcomes in transplant recipients. To determine the frequency of and risk factors for CMV reinfections, 205 seropositive women were followed up prospectively. The appearance of new antibody specificity against 1 of 4 polymorphic epitopes was considered as evidence of CMV reinfection. Approxima...

Human cytomegalovirus (CMV) is the most common cause of viral intrauterine infection and fetal damage largely attributable to maternal primary infection. Most cases of congenital CMV infection in twins reported in the literature involved only 1 twin. We assessed the validity of polymerase chain reaction (PCR) and quantitative PCR on amniotic fluid (AF), at 21 to 22 weeks' gestation and at least...

BACKGROUND Dried blood spots (DBS) may be valuable in the diagnosis of congenital cytomegalovirus (CMV) infection. However, the 2007 European Quality Control for Molecular Diagnostics (QCMD) proficiency testing programme showed that CMV DNA detection in DBS was lacking sensitivity in a considerable number of participating laboratories. OBJECTIVE To compare DNA extraction methods for DBS for d...

Cytomegalovirus (CMV) is recognized pathogen known for most common intrauterine infection in humans and vertical transmissions. We present a case of congenital CMV infection with bilateral cataract which is complicated by cholelithiasis which was later diagnosed on ultrasound examination of abdomen. This case is of particular interest because cholelithiasis has never been reported with CMV infe...

OBJECTIVE The objective of the study was to assess the effectiveness of ultrasound in the antenatal prediction of symptomatic congenital cytomegalovirus (CMV) infection. STUDY DESIGN The sonograms of 650 fetuses from mothers with primary CMV infection were correlated to fetal or neonatal outcome. Infection status was disclosed by viral urine isolation at birth or CMV tissue inclusions at auto...