AIMS To demonstrate the efficacy of mitomycin C as adjuvant therapy preoperatively and intraoperatively in the management of recurrent or diffuse ocular surface neoplasias. METHODS The case notes of 11 patients receiving mitomycin C adjuvant therapy as 0.04% eye drops four times a day in two weekly courses preoperatively and/or a single intraoperative application of 0.4 mg/ml of mitomycin C w...

BACKGROUND Melanosis of the uterine cervix is a rare, benign, melanocytic lesion of the cervix. A review of the English-language literature revealed 11 other reported cases. CASE A 52-year-old African American woman who presented for evaluation and treatment of menorrhagia was found to have an irregular, pigmented cervical lesion. The ectocervical biopsy showed melanosis characterized by hype...

Extensive melanosis of breast tissue due to melanin in the absence of involvement by melanoma either primary or secondary has been rarely encountered. Herein we report a first and unique case of extensive macroscopic and microscopic melanosis of mammary parenchyma between carcinoma cells due to melanin in a patient with a poorly differentiated invasive ductal carcinoma of the breast with no evi...

Radiol Bras. 2016 Nov/Dez;49(6):406–413 412 http://dx.doi.org/10.1590/0100-3984.2015.0139 the lesions by the paramagnetic contrast agent. Examination of the cerebrospinal fluid showed that there was no infection with Cryptococcus or any other agents, indicating an effective response to the treatment. The combination of clinical and radiological worsening, despite an effective treatment response...

OBJECTIVES To clinically evaluate topical mitomycin chemotherapy in patients with diffuse, multifocal, or recurrent primary acquired melanosis with atypia and/or conjunctival malignant melanoma and to histopathologically study ocular tissue samples obtained before and after treatment. METHODS Chemotherapy with topical mitomycin, 0.04% 4 times daily, was administered for 28 days as the primary...

A nevus is characterized by collection of partially differentiated or well-differentiated cells normally found in the skin. Some nevi are associated with disorders such as autism, epilepsy, ophthalmogical disorders, intracranial abnormalities, and others. In this case series, we aim to analyze six cases congenital nevus, matched our findings reports published reviewed literature, come a conclus...

Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic ...

A 20-year-old white female, who is an avid tanning-bed user, was referred for the evaluation of a pigmented lesion in her left eye. She reported occasional lid swelling, pain, tearing and light sensitivity for two years, which she attributed to wearing contact lenses. The patient received a diagnosis of ocular melanosis 6 months prior to her current presentation. On examination, the best-correc...