BACKGROUND Open-angle glaucoma appears to be induced by the malfunction of the trabecular meshwork cells due to injury induced by oxidative damage and mitochondrial impairment. Here, we report that, in fact, we have detected mitochondrial damage only in primary open-angle glaucoma and pseudo-exfoliation glaucoma, among several glaucoma types compared. METHODOLOGY/PRINCIPAL FINDINGS Mitochondr...

lent cause of visual impairment and blindness in the United States, after cataracts and macular degeneration from aging. Glaucoma is a progressive disease that causes optic-nerve head damage. Open-angle glaucoma affects 0.5% of the total US population but affects a much higher percentage (about 3%) in people aged 70 and older (1,2). Glaucoma is characterized chiefly by an increase in intraocula...

Primary glaucoma is one of the most common causes of irreversible blindness both in humans and in dogs. Glaucoma is an optic neuropathy affecting the retinal ganglion cells and optic nerve, and elevated intraocular pressure is commonly associated with the disease. Glaucoma is broadly classified into primary open angle (POAG), primary closed angle (PCAG) and primary congenital glaucoma (PCG). Hu...

Congenital herniation of the umbilical cord (CHUC) is a rare anomaly due to incomplete closure of umbilical ring and is different from abdominal wall defects. Intestinal atresias have been reported as a common associated anomaly. We herein present two cases hernia of umbilical cord associated with non-gastrointestinal anomalies. In one neonate, cleft lip and palate, PVID along with G6PD deficie...

PURPOSE Primary open-angle glaucoma (POAG) is the predominant form of chronic glaucoma, but the underlying pathologic mechanisms are largely unknown. Because prostaglandins (PGs) have been introduced into POAG treatment with remarkable success, this study was undertaken to investigate whether a change in the expression of the PG-synthesizing enzymes cyclooxygenase (COX)-1 and -2 might be involv...

PURPOSE To assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length. METHODS Human globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histol...

E Vázquez, MD, B. López, MD, L. Requena, MD, A. García-Pérez, MD, Dpto. Dermatología, Hospital Clínico ‘San Carlos’, E– 28040 Madrid (Spain) To the editor Described in 1922 [1], cutis marmorata telangiectatica congenita (CMTC) is a very rare disorder. It is characterized by: persistent cutis marmorata, phlebec-tasia and telangiectasias. Ulcers and atrophy are less frequently seen [2]. The disor...

-------------------------------------------------------------------ABSTRACT--------------------------------------------------------------Glaucoma is a disease associated with human eyes and second conducting movementofblindness across the globe if eyes are not treated at preliminary stage. Glaucoma normally occurs with increased intra-ocular pressure (IOP) in eyes and gradually damagesthe visio...

Cytochrome P450 1B1 (Cyp1b1) belongs to the CYP450 superfamily of heme-binding mono-oxygenases which catalyze oxidation of various endogenous and exogenous substrates. The expression of Cyp1b1 plays an important role in the modulation of development and functions of the trabecular meshwork (TM). Mutations in Cyp1b1 have been reported in patients with primary congenital glaucoma (PCG). Mice lack...