This study addresses the development of an animal model for human giant congenital nevomelanocytic nevi (GCNN). Skin grafts were made from 1) non-involved split-thickness skin from a 12-month-old GCNN patient, 2) nevus split-thickness skin from the same GCNN patient, 3) nevus full-thickness skin, and 4) cadaveric human split-thickness skin. For groups 1) and 2), human epidermal and dermal cells...

There are several benign lesions that may appear on conventional melanocytic nevi and clinically or histologically simulate malignant transformation while they actually behave in a benign manner.1 These include proliferative nodules, which show a particular tendency to develop on giant congenital melanocytic nevi (although they are also seen on smaller lesions) and, to a lesser degree, on acqui...

Although rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3-3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that developed on a giant congenital melanocytic nevus and made a metastasis to the subcutaneous tissue of ne...

An 8-day-old male infant was referred to our neonatal unit for prematurity. It was observed that his scalp color was darker than the rest of his skin color when the scalp hair was partially shaved for intravenous access. Dermatologic examination revealed a slightly elevated, hyperpigmented plaque confined to the whole scalp. The margin of the lesion did not extend to the face and neck. His hair...

Vellus hair follicle Accessory auricle Trichofolliculoma Hair nevus Abstract We present a case of hair follicle nevus, a rare hamartoma composed of vellus hair follicles. Hair follicle nevus should be differentiated from accessory auricle, trichofolliculoma and hair nevus. Masahiro Tani, MD, Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki-cho, 7 chome, Chuo-ku, Kobe 65...

BACKGROUND Nevus spilus (NS) is a potential precursor of melanoma; the vast majority of cases reported in the literature were histologically classified as superficial spreading melanoma. OBJECTIVE To demonstrate the diagnostic value of reflectance confocal microscopy (RCM) in this subtype of congenital nevi. METHODS We report a case of a large congenital NS with equivocal clinical and dermo...

Nevus of Ota is a hamartoma of dermal melanocytes. Clinically, Nevus of Ota is manifested as blue or gray patch on the face; such condition is congenital or acquired and is within the distribution of branches of the trigeminal nerve. The nevus can be unilateral or bilateral. In addition to skin, it may involve ocular and oral mucosal surfaces. The case of an 18-year old female with unilateral b...

Case 1: An area of pigment loss in the skin and surrounding hair is noted on the head of a 10-year-old boy. Examination of the vertex of the scalp reveals a nevus encircled by depigmentation. Can you identify this lesion? Case 2: During a routine skin examination, a suspicious-looking pigmented lesion is noted on the upper back of a 27-year-old man. The 4-cm, irregularly shaped lesion is compos...

The study of hair follicle tumors can be confusing, and hair follicle nevi are no exception. Analogous lesions frequently have divergent appellations. We evaluated the English-language literature on hair follicle nevi and histologic equivalents from 1921 to 1994. In addition, we reviewed four standard dermatopathology textbooks for further examples. We found 20 published valid cases of hair fol...