نتایج جستجو برای: connexin 26
تعداد نتایج: 167621 فیلتر نتایج به سال:
Connexins are tumor suppressors, and human breast connexin 26 (Cx26) and connexin 43 (Cx43) gap junctions are often down-regulated in breast cancer. We previously showed that Cx26 and Cx43 overexpressed in MDA-MB-231 breast cancer cells inhibited tumor growth in vivo but not in two-dimensional cultures. In the current study, we show that overexpression of Cx26 or Cx43 has tumor-suppressive prop...
BACKGROUND Deafness is the most common sensory disability in the world. Globally, mutations in GJB2 (connexin 26) have been shown to play a major role in non-syndromic deafness. Two other connexin genes, GJB6 (connexin 30) and GJA1 (connexin 43), have been implicated in hearing loss, but these genes have seldom been investigated in black Africans. We aimed to validate the utility of testing for...
Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1. Immunocytochemistry and quantitative PCR analysis of Cx30 KO mouse cultures revealed that Cx26 is downregulated at the protein level and at the mRNA level in nonsensory cells located between outer hair cells and the stria vascula...
abstract a cardiovascular problem is one of the common complications of diabetes. connexin is the predominant protein subunit in gap junction structure which is important in communication between cells. considering the role of connexin, this question can be created in the mind whether changes in phosphorylated connexin 43 occurs in diabetics thoracic aorta or not? 20 male wistar rats (30050g) ...
Mutations in the gene (GJB2) encoding connexin 26 (cx26) have been linked to sensorineural hearing loss either alone or as part of a syndrome. Here we compare the properties of four cx26 mutants derived from point mutations associated with dominantly inherited hearing loss, either non-syndromic (W44S, R75W) or with various skin disorders (G59A, D66H, R75W). Since cx26 and cx30 are co-localized ...
Gap junctional communication provides a mechanism for regulating multicellular activities by allowing the exchange of small diffusible molecules between neighboring cells. The diversity of gap junction proteins may exist to form channels that have different permeability properties. We report here that induction of terminal differentiation in mouse primary keratinocytes by calcium results in a s...
Hereditary deafness affects approximately 1 in 2,000 children. Mutations in the gene encoding the cochlear gap junction protein connexin 26 (CX26) cause prelingual, nonsyndromic deafness and are responsible for as many as 50% of hereditary deafness cases in certain populations. Connexin-associated deafness is thought to be the result of defective development of auditory sensory epithelium due t...
سابقه و هدف: افزایش فشار اکسیژن در کشت سلولی نسبت به حالت In vivo ، منجر به تغییراتی در بیان برخی از ژنها و متعاقب آن اختلال در عملکرد طبیعی سلولها میگردد. هدف از این مطالعه بررسی اثر هیپوکسی حاد 1% بر بیان ژنهای Connexin 43 و CXCR4 در سلولهای بنیادی مزانشیمی انسان در شرایط In vitro بوده است. مواد و روش ها: پس از کشت، گروهی از سلولهای بنیادی تحت تیمار هیپوکسی 1% به مدت 4، 8، 16، 24...
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