نتایج جستجو برای: connexin36
تعداد نتایج: 161 فیلتر نتایج به سال:
Combined confocal microscopy and freeze-fracture replica immunogold labeling (FRIL) were used to examine the connexin identity at electrical synapses in goldfish brain and rat retina, and to test for "co-localization" vs. "close proximity" of connexins to other functionally interacting proteins in synapses of goldfish and mouse brain and rat retina. In goldfish brain, confocal microscopy reveal...
The existence of functional connexin36 (Cx36) hemichannels in β-cells was investigated in pancreatic islets of rat and wild-type (Cx36(+/+)), monoallelic (Cx36(+/-)), and biallelic (Cx36(-/-)) knockout mice. Hemichannel opening by KCl depolarization was studied by measuring ATP release and changes of intracellular ATP (ADP). Cx36(+/+) islets lost ATP after depolarization with 70 mM KCl at 5 mM ...
Mammalian retinas contain abundant neuronal gap junctions, particularly in the inner plexiform layer (IPL), where the two principal neuronal connexin proteins are Cx36 and Cx45. Currently undetermined are coupling relationships between these connexins and whether both are expressed together or separately in a neuronal subtype-specific manner. Although Cx45-expressing neurons strongly couple wit...
45 A monumental task of the mammalian retina is to encode an enormous range (> 10 fold) 46 of light intensities experienced by the animal in the natural environment. Retinal neurons 47 carry out this task by dividing labor into many parallel rod and cone synaptic pathways. 48 Here we study the operational plan of various rod and cone mediated pathways by 49 analyzing electroretinograms (ERGs), ...
Cone photoreceptors are electrically coupled such that when the electrical potential in one cell changes, it also changes in adjacent, coupled cells. Phosphorylation of the cone gap junction protein, connexin 36 (Cx36), determines whether a coupling channel is “open” or “closed”. Cx36containing gap junctions are phosphorylated in the open state and dephosphorylated in the closed state. Cone-con...
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