Introduction Pro: HFOV Offers Benefits Over Conventional Ventilation in Adult Patients With ARDS Principles of Lung-Protective Ventilation Small VT Improved Alveolar Recruitment Decreased Lung Inflammation Summary of the Pro-HFOV Position Con: HFOV Offers No Benefit Over Conventional Ventilation in Adult Patients With ARDS Strength of the Evidence Rescue Therapy Effect of HFOV on Inflammation R...

In seven postoperative patients with normal preoperative pulmonary function tests, we evaluated the oxygen cost of breathing (VO2resp) during continuous positive pressure ventilation (CPAP) and during a 15 cm H2O inspiratory pressure support ventilation (IPSV). For both periods, VO2 resp was estimated as the difference between total oxygen uptake of the period (VO2tot), measured by a mass-spect...

Objective: To review the evidence as to whether early extubation with immediate application of non-invasive ventilation reduces mortality and ventilator-associated pneumonia and improves other outcomes in criticallyill adults receiving invasive ventilation. Data sources: Medline, Embase, CENTRAL, searched up to April, 2008. This search was supplemented by hand-searching of conference proceeding...

BACKGROUND Noninvasive positive-pressure ventilation (NPPV) unloads respiratory muscles. Spontaneous-breathing ventilation modes require patient effort to trigger the ventilator, whereas controlled modes potentially economize on patient triggering effort and thus achieve more complete respiratory muscle rest. Data on controlled NPPV have not been published to date. We hypothesize that controlle...

Methods Objective: The aim of the study was to determine whether lung-protective ventilation improves outcomes in anesthetized patients undergoing major abdominal surgery. Design: The Intraoperative Protective Ventilation (IMPROVE) trial is a multicenter, open-label double-blind, parallel-group randomized control trial in seven French university hospitals. Setting: The IMPROVE study enrolled 40...