Heme synthesis by copper-deficient cells was investigated to elucidate the nature of the defect in intracellular iron metabolism. Iron uptake from transferrin by copper-deficient reticulocytes was 52% of normal, and the rate of heme synthesis was 33% of normal. Hepatic mitochondria isolated from copper-deficient animals were deficient in cytochrome oxidase activity and failed to synthesize heme...

Bleomycin is widely used for treating several types of human tumors as well as a variety of experimental tumors. The ability of this antibiotic to bind and to damage DNA has been proposed to be responsible for its antitumor effect. Bleomycin is also a good chelator for several metals, e.g., iron, copper, and others. Bleomycin:metal complexes have been investigated in detail particularly for the...

Chelates can inhibit the iron- and copper-catalyzed autoxidation of ascorbate at pH 7.0. Diethylenetriaminepentaacetic acid (DTPA or DETAPAC) and Desferal (deferoximane mesylate) slow the iron-catalyzed oxidation of ascorbate as effectively as reducing the trace levels of contaminating iron in buffers with Chelex resin. DETAPAC, EDTA and HEDTA (N-(2-hydroxyethyl)-ethylenediaminetriacetic acid) ...

On the one hand, copper slag is nowadays a waste in pyrometallurgy despite significant quantities of iron (>40 wt. %) and (1 to 2 %). other solar energy, when properly concentrated, offers great potential high-temperature processes. Therefore, concentrated power (CSP) could be used treatment transform fayalite into magnetite sulfides oxides nodules. This objective this paper. The results sho...

A 66-year-old woman with a history of obesity status post–gastric bypass presented with pancytopenia and no evidence of myeloneuropathy. A bone marrow biopsy was performed to exclude myelodysplastic syndrome (MDS) and showed no excess blasts and several vacuolated granulocytic (red arrow) and erythroid (yellow arrows) precursors with occasional megaloblastic change. Folate and vitamin B12 level...

The utility of employing biogenerated ferric iron as an oxidant for the recycling of scrap metal has been demonstrated using continuously growing cells of the extremophilic organism Acidithiobacillus ferrooxidans. A ferric iron rich (70 mol%) lixiviant resulting from bioreactor based growth of A. ferrooxidans readily solubilized target scrap metal with the resultant generation of a leachate con...

OBJECTIVE To describe the frequency of anemia and iron, zinc, copper and magnesium deficiencies among Mexican adolescents in the probabilistic survey ENSANUT 2006. MATERIALS AND METHODS The sample included 2447 adolescents aged 12 to 19 y. Capillary hemoglobin and venous blood samples were collected to measure the concentrations of ferritin, sTFR, CRP, zinc, iron, copper and magnesium. Logist...

Three experiments involving 296 pigs were conducted to determine the related effects of copper sulfate and ferrous sulfide on performance and liver copper and iron stores of growing-finishing pigs, and the effect of ferrous sulfide on the depletion of copper from the liver. The dietary addition of 250 ppm copper alone improved growth rate by 9.2% (621 vs 678 g/day) and feed to gain ratio by 3.3...

Adverse outcomes of pregnancy increase among women with high density of hemoglobin. This study evaluates the effects of iron supplementation on serum copper level in pregnant women with hemoglobin higher than 13.2 g/dl. Sixty two pregnant women with Hemoglobin >13.2 g/dl and normal serum copper levels in their 13-18 weeks of gestation were randomized into case and control groups. From 20th week...