DESCRIPTION A 49-year-old man who sustained an alkali burn to both eyes after falling face first into a bucket of calcium hypochlorite solution (pH = 11.8) while cleaning his pool.

PRECIS During the 4 years of this study, we noted 66 cases of alkali ocular burns, or approximately 16 cases per year, nearly half (45.5%) of which are due to an assault. For grade 1 and 2 burns the time elapsed to reepithelialization appears to be shorter when rinsed with Diphoterine* versus physiological solution. PURPOSE Comparison of the effectiveness of two rinsing solutions for emergenc...

IkB kinase β (IKKβ) is a key signaling kinase for inflammatory responses, but it also plays diverse cell type-specific roles that are not yet fully understood. Here we investigated the role of IKKβ in the cornea using Ikkβ(ΔCS) mice in which the Ikkβ gene was specifically deleted in the corneal stromal keratocytes. The Ikkβ(ΔCS) corneas had normal morphology, transparency and thickness; however...

PURPOSE To develop a device that facilitates the procurement of corneal limbal stem cell grafts for keratolimbal allograft procedures used in the treatment of ocular surface disease associated with stem cell deficiency. DESIGN Description of device design and technique for use. METHODS The device is composed of a pedestal with a convex surface mounted to a flat platform. A corneoscleral but...

OBJECTIVE To highlight the case of a sports-related alkali burn due to a common household chemical and emphasize the importance of a detailed medical history in chemical burns patients. METHODS A single-patient case study is presented along with references from existing literature. RESULTS Alkaline burn injuries associated with sports have previously been described in the literature; howeve...

Abstract The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering most corneas receiving grafts are either pathological or inflamed before implantation, the risk rejection heightened. Here, we show bioengineered, fully synthetic, and robust corneal be manufactured from a collagen analog (collagen-like peptide-po...

The two main issues that concern glaucoma patients before and after penetrating keratoplasty and posterior lamellar procedures and patients that develop glaucoma after surgery are the risks of graft failure and the aggravation of the glaucoma. Failure of the corneal graft may require regrafting, which increases the risk of developing or aggravating glaucoma, while uncontrolled glaucoma may resu...