IN 1963 our out-patients department was visited by a 27-year-old man with a corneal foreign body. On slit-lamp examination, both corneae appeared to be studded with numerous tiny, grey-white points, which were situated in the epithelium. In retrolight they appeared as fine, round, or somewhat irregular vesicles or droplets spread over the entire corneal surface, apart from the limbal area. Towa...

PURPOSE To report the clinicopathological findings of a Chinese patient with an unusual phenotype of gelatinous drop-like corneal dystrophy (GDLD) combined with spheroidal degeneration and to detect molecular defect in the tumor-associated calcium signal transducer 2 (TACSTD2) gene. METHODS Extensive physical and ophthalmologic examination of the patient was performed. Initially superficial k...

IN 1963 our out-patients department was visited by a 27-year-old man with a corneal foreign body. On slit-lamp examination, both corneae appeared to be studded with numerous tiny, grey-white points, which were situated in the epithelium. In retrolight they appeared as fine, round, or somewhat irregular vesicles or droplets spread over the entire corneal surface, apart from the limbal area. Towa...

purpose: to report the possible transmission of zygomycetes infection by a corneal graft harvested from a donor with signs of trauma to the orbital region to a keratoconic patient who underwent deep anterior lamellar keratoplasty (dalk). case report: a 19-year-old keratoconic man underwent dalk in the right eye. the corneal graft was harvested from a donor with signs of orbital trauma. on posto...

Inherited retinal and corneal dystrophies represent a group of disorders with great genetic heterogeneity. Over 250 genes are associated with retinal diseases and 16 genes are causative of corneal dystrophies. This thesis is focused on finding the genetic causes of corneal dystrophy, Leber congenital amaurosis (LCA), Stargardt disease and retinitis pigmentosa in families from northern Sweden. B...

A three-dimensional gel contraction model was used to evaluate interactions between human keratocytes and different kinds of collagen in the presence or absence of various growth factors. Bovine collagen type I or human placental copolymerized collagen type I/III was used to create the lattices. Normal keratocytes from neonatal, aged, and insulin-dependent diabetic donors, as well as abnormal k...

The corneal endothelium serves primarily in maintaining stromal deturgescence which is essential for transparency of cornea. Any disturbance in its function leads to stromal edema which in turn reduces vision. The genetically heterogeneous nature of four different kinds of corneal endothelial dystrophies represents the involvement of diverse set of genes. Until now, only few genes were identifi...

Persistent corneal edema is one of the complications of phacoemulsification. Five patients underwent this procedure 6 to 8 months before keratoplasty was performed. In addition to bullous keratopathy, two corneas had corneal scarring due to probe overheating or corneal vascularization of the anterior chamber. Electron microscopy of corneal specimens showed that four cases had Fuch's dystrophy w...

BACKGROUND The molecular basis of Meesmann's epithelial corneal dystrophy (MECD) has recently been attributed to mutations in the cornea specific keratin genes KRT3 and KRT12. The mechanisms by which these mutations cause the Meesmann's phenotype are not clear. This study presents new data, examines clinical, histological, ultrastructural, and molecular aspects of MECD, and compares the feature...