The high incidence of double-gene deletions in α-thalassaemia increases the risk of having pregnancies with homozygous α(0)-thalassaemia, the cause of the lethal haemoglobin (Hb) Bart's hydrops fetalis syndrome. Preimplantation genetic diagnosis (PGD) has played an important role in preventing such cases. However, the current gap-PCR based PGD protocol for deletional α-thalassaemia requires spe...

A case with a pleural effusion and hydrops fetalis has been presented. Good outcome had been achieved by a single thoracentesis and a healthy baby w as delivered at the 39th w eek of pregnancy. In a fetus with a pleural effusion and hydrops fetalis, normal like echogenic view of the affected side lung and lung expansion during aspiration without any signs of fetal distress are good prognostic s...

Non-immune fetal hydrops is diagnosed when there is fluid accumulation in more than one extravascular space. A long list of etiologies has been found in association with non-immune hydrops. Thorough investigations are needed to be able to identify an underlying cause. There are many recent reports indicating that non-immune hydrops can be an extreme presentation of a number of metabolic disorde...

There is increasing evidence that hormonal influences may play a key role in the pathogenesis of corneal ectasia.1,2 Furthermore, transitory corneal topographical variations due to hormonal influences during pregnancy have been recently reported.3 We highlight a case of corneal topographic fluctuations associated with exacerbated hypothyroidism. A 47-year-old woman without medical history was r...

OBJECTIVE The purpose of this study is to evaluate the effect of prenatal steroid treatment in fetuses with sonographically diagnosed congenital cystic adenomatoid malformations (CCAMs). METHODS This was an institutional review board-approved retrospective review of 372 patients referred to the University of California, San Francisco (UCSF), for fetal CCAM. Inclusion criteria were (1) a predo...

UNLABELLED In experimental endolymphatic hydrops distortion-products otoacoustic emission (dpoae) amplitudes decrease and there is elevation on electrocochleographic thresholds. Some authors found type ii nitric oxide synthase (nos ii) expression in hydropic cochleas and they suggest nitric oxide (no) may be involved in endolymphatic hydrops pathogenesis. The aim of this study was to evaluate t...

OBJECTIVE Holoprosencephaly is a kind of brain anomaly characterized by inadequate cleavage of the prosencephalon during early embryogenesis. In addition, holoprosencephaly associated with cystic hygroma and hydrops fetalis has never been reported. In this article, we report a rare case of holoprosencephaly associated with cystic hygroma and hydrops fetalis diagnosed prenatally. CASE REPORT A...

Electrocochleography (ECoG) has been an important tool in the diagnosis of Meniere’s disease or endolymphatic hydrops. There are two methods employed, transtympanic and extratympanic. Many have regarded the results of these methods as being equally reliable. The purpose of this study is to determine any differences in sensitivity between the two methods. In this study patients with known endoly...

Non-immune hydrops fetalis is defined as presence of excess fluid in two or more body areas, such as the abdomen, thorax, or skin, excluding immune etiology. Major causes of non-immune fetal hydrops are fetal heart diseases and abnormal chromosome. In spite of accumulated reports of fetal magentocardiograms (FMCG) for heart diseases, FMCG for fetal hydrops of non-cardiac origin has seldom been ...