PURPOSE The purpose of this study was to determine the efficacy of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), in prevention of excessive wound healing and scar formation in a rabbit model of glaucoma filtration surgery (GFS). METHODS A rabbit model of GFS was used. Rabbits that underwent GFS received balanced salt solution, or SAHA (50 μM), or mitomycin C...

BACKGROUND Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features. CASE PRESENTATION Patient charts of five cases of microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical ...

A rare case of fungal keratitis caused by Plectosporium tabacinum is reported. A 78-year-old female gardener presented with conjunctivitis and an oval infiltrate with irregular margins in the nasal half of the cornea in the right eye. Light microscopy of corneal scrapings revealed a filamentous fungus, and a diagnosis of fungal keratitis was made. The patient was admitted into our hospital on F...

INTRODUCTION We report a rare cause of keratitis, due to Cylindrocarpon lichenicola, in a farmer with keratomycosis. Despite the acknowledged virulence of this fungus, a suitable antifungal for its management was not accessible. CASE PRESENTATION A 67-year-old farmer presented with a two-week history of pain, mucopurulent discharge, redness and a corneal ulcer with a visual acuity of hand mov...

Mr Massae (not his real name) is a forty-eight year old farmer who recently presented at a tertiary ophthalmology unit in Tanzania with a three-week long history of pain, purulent discharge, and loss of vision in the left eye. Several days after the onset, he had received treatment from his local health centre (chloroamphenicol drops), but his eye continued to get worse. At presentation, he had...

background and aims: herpes simplex virus (hsv) is a common cause of corneal disease and is the leading infectious cause of corneal blindness among developed nations. this study is aimed to provide an estimation of the incidence of herpes simplex virustype-1, 2(hsv1, 2) and varicella zoster virus (vzv) in tears and swab from eye infection by polymerase chain reaction (pcr) in eye disease in a s...

purpose: to evaluate the results of keratoprosthesis (kps) at labbafinejad medical center. method: in this case-series 29 eyes of 27 patients who underwent kps between 1995-2002 were evaluated for results and complications. results: patients included 22 male and five female subjects. diagnoses included chemical burn (17 cases), stevens-johnson syndrome (three cases), ocular cicatricial pemphigo...

Deep anterior lamellar keratoplasty (DALK) is a surgical technique for cornea replacement, which the healthy host corneal endothelium is preserved. Keratoconus patients are those who benefit most from a successful DALK procedure, once the endothelium of these patients is usually normal and should therefore be maintained. Several studies comparing visual outcomes between penetrating keratoplasty...