INTRODUCTION There is a need to find alternatives to the use of human donor corneas in transplants because of the limited availability of donor organs, the incidence of graft complications, as well as the inability to successfully perform corneal transplant in patients presenting limbal deficiency, neo-vascularized or thin corneas, etc. We have designed a clinical trial to test a nanostructured...

ABSTRACT The objective in this study was to evaluate the clinic effect of applying allogenic platelet-rich plasma (PRP) heated or not, for treating cornea ulcers, including dosage PDGF-BB cornea. ulcers were induced, standardizing left eye from 81 rats (Ratus norvegicus, albinus variety), assigned randomly into three groups (N=27): control group (CG) which did not receive any topic treatment; P...

Amniotic membrane transplantation (AMT) leads to reduction of inflammatory symptoms and causes faster epithelisation in corneal ulcers and persistant epithelial defect. 21 patients with corneal ulcer (n = 18) or non-healing epithelial defect (n = 3) unresponsive to conventional treatment were included in the study. All patients were treated by AMT. Corneal epithelial cells in patients suffering...

Contact lens type amniotic membrane (CLAM) is a promising new approach to using in ophthalmology. It can be used treat range of ocular surface disorders, including dry eye disease, corneal ulcers, and chemical burns. CLAM help reduce inflammation, promote epithelialization wound healing, improve clarity vision. Its ease handling application, combined with its potential therapeutic benefits, mak...

The article summarizes the most up-to-date scientific research data, clinical experience of foreign colleagues and author regarding indolent corneal ulcer in dogs. modern view on etiopathogenesis pathology is disclosed detailly. signs forms chronic epithelial defects (CCED) are described. entire list drugs used for therapeutic treatment dogs with CCED presented. Along this, indicated use which ...

Background: Pseudomonas aeruginosa have a significant proportion of the causes bacterial keratitis. Corneal ulcers infected with P. are more severe than other corneal ulcers. is often associated keratitis that results from wearing contact lenses, which eventually leads to This study aims determine differences in antibiotic sensitivity test scraping specimens patients using lenses and non-contac...

Ascorbic acid, a water soluble vitamin, helps in collagen assembly, synthesis of neurotransmitters, has immune functions and also acts as a major antioxidant in the body. Refractory corneal ulcer is a challenging situation faced by every ophthalmologist in developing countries. Available treatment options for refractory corneal ulcer are bandage contact lens, grid keratotomy, therapeutic penetr...

Patients hospitalized in the Intensive Care Unit (ICU) may present risk for corneal injury due to sedation or coma. This study aimed to estimate the incidence of corneal injuries; to identify the risk factors and to propose a risk prediction model for the development of corneal injury, in adult patients, in an intensive care unit of a public hospital. This is a one year, prospective cohort stud...

PURPOSE A recent clinical report demonstrated that topical nerve growth factor (NGF) treatment in patients affected by corneal neurotrophic ulcers induced epithelial and stromal healing restoring corneal integrity. Mechanisms(s) undergoing these clinical NGF actions are still unclear. The aim of this study was to investigate the role of NGF in human and rat cornea physiopathology. METHODS Exp...