AIMS To investigate the role of angiotensin converting enzyme (ACE) (I/D) gene polymorphism in the development of coronary sclerosis after cardiac transplantation. METHODS AND RESULTS Eighty cardiac transplant recipients (44 transplant associated coronary artery disease; 36 non-transplant associated coronary artery disease) and their donors were genotyped by polymerase chain reaction. The all...

Background: Differences in the prevalence and impact of hyperhomocytenemia on vascular disease between countries and races have been reported. Most studies have been undertaken in North American and European populations and the importance of plasma total homocysteine (tHcy) level as a risk factor for coronary artery disease in the Middle East particularly in Iran, however, is not known.  Object...

coronary artery calcium scoring (cacs) is a reasonable test for patients with the possibility of atherosclerosis. it can also be used for reclassifying the coronary artery disease (cad) to the high-risk status by higher cacs and subsequently modifying the management of the patients.the purpose of this study was to investigate the association of cacs to the severity of coronary artery disease in...

BACKGROUND AND OBJECTIVES Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. SUBJECTS AND METHODS A total of 646 patients who underwent coronary angiography were included in this study. Coronary ...

coronary artery disease is one of the main causes of mortality in most developed countries. there is also an increasing rate of mortality in developing countries where in addition to coronary artery disease, infection diseases still not have been controlled. although, now a day coronary artery disease is responsible for half of deaths in developed countries, this regrettable event is increasing...

impaired fasting glucose identifies individuals at high risk of progression to diabetes but the role of ifg as a coronary artery disease risk factor, independent of its progression to diabetes and its association with other coronary artery disease risk factors ,is unclear. a cross-sectional study was conducted to evaluate the hypothesis that impaired fasting glucose increased the likelihood of ...

Both the processes of atherosclerosis and plaque rupture are indicated to be influenced by matrix metalloproteinase (MMP) activity. We therefore searched for common functional variation in the matrix metalloelastase (MMP-12) gene locus that may be implicated in coronary artery disease. Single-strand conformation polymorphism analysis of DNA from healthy individuals detected a common polymorphis...

Great personal enthusiasm, temptation, technical efforts, and complex mathematical equations characterize the developing research field of newly identified gene polymorphisms and their impact on a variety of cardiovascular diseases. After the first publication of Cambien and coworkers1 in Nature in 1992, who reported that the D/D angiotensinconverting enzyme (ACE) polymorphism is a potent risk ...

Lipid status and apolipoprotein E phenotypes were tested in 1000 patients who underwent coronary angiography. The same number of factory employees was chosen as a control group. We distinguished between six different apolipoprotein E phenotypes and determined their frequencies in all groups. For the three homozygous phenotypes E3/3, E4/4, and E2/2, the percentage distribution in the group of fa...