Using a fluorescence method called colocalization single-molecule spectroscopy (CoSMoS), Friedman and Gelles dissect the kinetics of transcription initiation at a bacterial promoter. Ultimately, CoSMoS could greatly aid the study of the effects of DNA sequence and transcription factors on both prokaryotic and eukaryotic promoters.

Most biological information is contained within gene and genome sequences. However, current methods for analyzing these data are limited primarily to the prediction of coding regions and identification of sequence similarities. We have developed a computer algorithm, CoSMoS (for context sensitive motif searches), which adds context sensitivity to sequence motif searches. CoSMoS was challenged t...

in order to determine the resistance levels and the most suitable potato genotypes to the early blight, an experiment was conducted in a completely randomized factorial design with three replications, in national plant gene bank of iran during 2007-2008. factors included pathogenic fungus, a. tenuissima and a. alternata and six potato genotypes, picasso, marfona, delta, agria, cosmos and armida...

Introduction: Quantitative Susceptibility Mapping (QSM) provides both visualization and quantification of endogenous and exogenous susceptibility contrast. Finding the susceptibility distribution from the measured field map requires a deconvolution of that field map with the unit dipole response, a process which is ill-posed [1]. Several techniques have been proposed to solve the problem by mul...

The basic CoSMoS process concerns the design, implementation, and use of a simulation built from scratch. However, the CoSMoS approach may be tailored and adapted for other styles of use. Here we describe how it has been applied to analyse and re-engineer an existing simulation, that of Schelling’s Bounded Neighbourhood Model. We find that using a principled approach to the analysis of an exist...

Computer simulation approaches are starting to be used more extensively throughout scientific investigations. Some scientists, however, are skeptical about the benefits of simulation. We present computer simulation as a scientific instrument in order to explore issues of their construction and use, which we believe might increase their acceptance within science. We highlight the need to underst...