BACKGROUND Lung cancer remains a devastating disease with few effective treatment options. Recent developments in chemotherapy have led to cautious optimism. This paper reviews the evidence on the clinical and cost effectiveness of four of the new generation drugs for patients with lung cancer. METHODS A systematic review of randomised controlled trials (RCTs) identified from 11 electronic da...

The US government must act to curb the soaring cost of anticancer drugs, 118 US oncologists have argued in a commentary published on 23 July inMayo Clinic Proceedings. The authors include leading oncologists from such institutions as the University of Texas MD Anderson Cancer Center in Houston,Memorial Sloan Kettering Cancer Center in NewYork City, and Dana-Farber Cancer Institute and Harvard M...

Cancer is the one of the major causes of death worldwide. More than 16 million new cancer cases are expected by 2020, and it is estimated that cancer will then be the cause of more than 10 million deaths per year1. Cancer has become the leading cause of death in Canada. According to the Canadian Cancer Society, 40% of men and 45% of women are expected to develop cancer during their lifetime2. W...

Optimizing drug combination treatment has been an area of interest for a while, from the beginning with emergence POMP regime. The ability to improve combinations cancer comes up against possibility several limitations, such as lack specificity drugs, generating systemic toxic effects, and also great tumor cells resistant drugs. development nanooncology offers advances in new alternatives cance...

The purpose of this study was to compare the efficacy, safety, and cost of piperacillin/tazobactam with cefepime monotherapy in children with febrile neutropenia. A prospective randomized study in children and adolescent with cancer was conducted. Patients were randomly assigned to receive either 80 mg/kg piperacillin/10 mg/kg tazobactam every 6 h (maximum 4.5 g/dose) or cefepime 50 mg/kg every...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

Our study aimed to analyze and compare monthly costs along with cost variation between Ayurveda Allopathy medicines used treat 2 chronic disease conditions, viz. Rheumatoid Arthritis Hypertension. The prices of Allopathic & Ayurvedic drugs mentioned in the treatment guidelines for these conditions were obtained from different sources. minimum maximum a particular drug same strength manufact...

Many new cancer drugs provide only limited benefits, but at very great cost, for example, $200,000-$300,000 per quality-adjusted life year produced. By most standards of value or cost-effectiveness, this does not represent good value. I first review several of the causes of this value failure, including monopoly patents, prohibitions on Medicare's negotiating on drug prices, health insurance pr...

Several promising anticancer drug candidates have been sidelined owing to their poor physicochemical properties or unfavorable pharmacokinetics, resulting in high overall cost of drug discovery and development. Use of alternative formulation strategies that alleviate these issues can help advance new molecules to the clinic at a significantly lower cost. Tylocrebrine is a natural product with p...