نتایج جستجو برای: cox 1
تعداد نتایج: 2783617 فیلتر نتایج به سال:
Colorectal cancer is one of the most common cancers in the world. Various factors are involved in the development and progression of this disease. One of these agents is cyclooxygenase-2 (COX-2). COX-2 is a product of the PTGS2 gene and converts free arachidonic acid to prostaglandins. COX-2 is not naturally expressed in most normal cells. Noticeably, the increased expression of COX-2 has been ...
مقدمه:کنترل موثر درد بعد از جراحیهای دهانی یکی از بزرگترین مشکلات در دندان پزشکی محسوب میشود. ibuprofenامروزه معروفترین داروی غیرانتخابی ضدالتهابی غیراستروئیدی(nsaid) میباشد که هر دو آنزیم cox-1 و cox-2 را مهار میکند. celecoxib تنها مهارکننده اختصاصی cox-2 در ایران است و ناپروکسن هم جزء nsaidهای غیرانتخابی است که در ایران معمولاً به عنوان انتخاب اول درمان ضددردی نمیباشد. هدف از این مطالع...
Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals that likely inhibit COX-2 presumably not been associated with adverse cardiovascular side effects....
Cox-1 and Cox-2 specific inhibitors exert chemo-preventative activity. However, the exact mechanisms for this activity remain unclear. Increasing evidence suggests that non-steroidal anti-inflammatory drugs regulate gene expression, which may be responsible, in part, for this activity. In this study, human colorectal carcinoma HCT-116 cells were treated with the Cox-1 specific inhibitor SC-560 ...
Non-steroidal anti-inflammatory drugs (NSAIDs) attenuate tumor net growth in clinical and experimental cancer. Evaluations in cell culture experiments have implied involvement of growth factor and G-protein related signaling pathways to explain decreased proliferation, angiogenesis, increased cell adhesion and apoptosis. Sparse information is however available from studies on growing tumors in ...
background: cox proportional hazard (cph) model is the most widely used model for survival analysis. when there are unobserved/unmeasured individuals factor, then the results of the cox proportional hazard model may not be reliable. the purpose of this study was to compare the results of cph and frailty models in breast cancer (bc) patients. methods: a historical cohort study was carried out us...
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