In rodents, a conditioned place preference (CPP) can be induced by morphine. In the current study, we designed a biased place conditioning paradigm to test the rewarding effects of morphine in freely moving rhesus monkeys. Five monkeys were first placed in three serial rooms with the doors open between them for three days. After this habituation period, during which baseline preference for each...

A cell-penetrating peptide (CPP)-morpholino oligonucleotide (MO) conjugate (PMO) that has an antibiotic effect in culture had some contaminating CPPs in earlier preparations. The mixed conjugate had gene-specific and gene-nonspecific effects. An improved purification procedure separates the PMO from the free CPP and MO. The gene-specific effects are a result of the PMO, and the nonspecific effe...

Gonadotropin-releasing hormone analogs (GnRHa) are widely used to treat central precocious puberty (CPP). The efficacy and safety of GnRHa treatment are known, but concerns regarding long-term complications are increasing. Follow-up observation results after GnRHa treatment cessation in female CPP patients up to adulthood showed that treatment (especially <6 years) was beneficial for final adul...

Reconfiguration of extracellular matrix proteins appears to be necessary for the synaptic plasticity that underlies memory consolidation. The primary candidates involved in controlling this process are a family of endopeptidases called matrix metalloproteinases (MMPs); however, the potential role of MMPs in nicotine addiction-related memories has not been adequately tested. Present results indi...

UNLABELLED Recently, it was shown that D-cycloserine (DCS, a NMDA partial agonist) facilitated extinction of fear as well as cocaine conditioned place preference (CPP) in rats. METHODS The present study examined the effects of DCS (15 mg/kg i.p. and 30 mg/kg i.p.) on extinction and renewal of cocaine-induced CPP in C57bL/c mice. In parallel, we examined the effects of DCS on locomotor activit...

THE cerebral perfusion pressure (CPP; mean arterial pressure intracranial pressure) is a major determinant of cerebral perfusion in the injured brain. Several recent studies have attempted to provide data on optimal CPP targets within the context of protocols for the intensive care management of severe traumatic brain injury. The report by Nordström et al. in this issue of ANESTHESIOLOGY adds t...

Central precocious puberty (CPP) is commoner in girls in comparison to boys. Its Causes are idiopathic in over 80% girls while being secondary to central nervous system pathologies in 80% boys. CPP in association with empty sella syndrome, a condition often linked with idiopathic intracranial hypertension, is rare. We report a case of a boy with CPP and recurrent headaches in whom empty sella w...

Narp knockout (KO) mice demonstrate an impaired extinction of morphine conditioned place preference (CPP). Because the medial prefrontal cortex (mPFC) has been implicated in extinction learning, we tested whether Narp cells in this region play a role in the extinction of morphine CPP. We found that intracranial injections of adenoassociated virus (AAV) expressing wild-type (WT) Narp into the mP...

Chronic pelvic pain (CPP) has many potential causes and is often a complex disorder with multiple contributing etiologies. The evaluation and treatment of women with CPP often requires a multidimensional approach. The treatment of CPP consists of two approaches: 1) treatment of pain itself or global treatment, and 2) treatment of disease-specific etiologies. Most often, treatment requires a com...