Increasing quinolone resistance has been reported worldwide, mainly among clinical isolates of Escherichia coli. The objectives of this study were to determine the susceptibility profile, the genetic relatedness, and the prevalence of the qnr gene among ciprofloxacin-resistant Escherichia coli isolated from distinct Brazilian hospitals. A total of 144 ciprofloxacin-resistant Escherichia coli we...

Caloric restriction (CR) has received much interest as an intervention that delays age-related disease and increases lifespan. Whole-genome microarrays have been used to identify specific genes underlying these effects, and in mice, this has led to the identification of genes with expression responses to CR that are shared across multiple tissue types. Such CR-regulated genes represent strong c...

Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the en...

Objectives:Citrobacter spp. especially Citrobacter freundii, is frequently causing nosocomial infections, and increasingly becoming multi-drug resistant (MDR). In this study, we aimed to determine the genetic diversity and relationships of Citrobacter spp. from diarrheal patients and food sources, their antimicrobial resistance profiles and in vitro virulence properties. Methods: Sixty two Citr...

Sir, CTX-M-15 is an extended-spectrum b-lactamase (ESBL) extensively reported in humans, and in particular in Escherichia coli clones of sequence types (STs) ST131 and ST405. The blaCTX-M-15 gene has also become prevalent in Klebsiella pneumoniae, causing outbreaks in hospitals worldwide. – 4 In animals, a highly prevalent ESBL gene is the blaCTX-M-1 gene, with the blaCTX-M-15 gene also being f...

Background: Many bacteria can cause urinary tract infections (UTIs), among which Escherichia coli is the most common causative agent. strains are divided into eight phylogenetic groups based on new Quadroplex-PCR method, different in terms of patterns resistance to antibiotics, virulence, and environmental characteristics. Objectives: This study aimed determine prevalence drug genes E. causing ...

Objective: To genotypically assess the relationship between certain resistance and virulence determinants.Method: The cross-sectional study was conducted at Kafrelsheikh University, Egypt, from March 2019 to May 2021, comprised pathological samples, like blood, sputum, urine, vaginal swabs wound swabs, that had been taken patients who never received treatment. sample were collected Mansoura Uni...

The gene qnr (qnrA [G. A. Jacoby, K. Walsh, D. Mills, V. Walker, A. Robicsek, H. Oh, and D. C. Hooper, Abstr. 44th Intersci. Conf. Antimicrob. Agents Chemother., abstr. C2-1898a, 2004]; encoding QnrA) was first identified as a transferable quinolone resistance determinant on a multidrug-resistant plasmid in Klebsiella pneumoniae (6, 9) and has been detected in K. pneumoniae, Escherichia coli, E...

A total of 91 non-typhoid Salmonella isolated from pediatric patients with diarrhea in Seoul from 2003 to 2009 was tested for antimicrobial susceptibility of nalidixic acid (NA). Forty strains of NA resistance or intermediate susceptible non-typhoid Salmonella were identified and their minimum inhibitory concentrations (MICs) of NA, ciprofloxacin (CIP), and norfloxacin (NOR) were determined. Of...