from serial changes in plasma creatine phosphokinase activity. Acta Med Scand 587: 151-166, 1975 13. Roberts R, Sobel BE: Effect of selected drugs and myocardial infarction on the disappearance of creatine kinase from the circulation in conscious dog. Cardiovasc Res 11: 103-112, 1977 14. Sobel BE, Shell WE, Klein MS: An isoenzyme of creatine phosphokinase associated with rabbit heart mitochondr...

OBJECTIVES In this study, we aimed at evaluation of electrophysiological and histopathalogical characteristics of statin-induced muscle injury as well as clinical features of patients who develop this condition in terms of frequency and pattern of evolution. MATERIALS AND METHODS Forty patients (age 39-74 years) including 25 subjects with type 2 diabetes mellitus, 9 with cardiovascular diseas...

A 71-year-old male who had a bile-duct cancer with liver metastases underwent systemic chemotherapy with cisplatin (25 mg/m) followed by gemcitabine (GC) (1000 mg/m). Two days after the first administration, he complained of ‘crampy’ abdominal pain. White blood cell count and levels of C-reactive protein and liver enzymes were elevated but those of creatine phosphokinase and lactate Figure 1. J...

Hypocalcemic cardiomyopathy is a rare entity. We describe a patient with severe heart failure, decreased ejection fraction and global hypokinesia documented on echocardiogram, associated with severe hypocalcemia, very low vitamin D status, increased QT intervals, increased BNP (serum brain natriuretic peptide) levels and CPK (creatine phosphokinase) levels. All these defects reversed on treatme...

1 HFAR Hospital das Foras Armadas, Azinhaga Ulmeiros, 1620-060 Lisboa, Portugal [email protected] 2 ALGORITMI Research Centre, Department of Information Systems, University of Minho, 4800-058 Guimarães, Portugal [email protected] WWW home page: http://www3.dsi.uminho.pt/pcortez 3 Business Research Unit (UNIDE-IUL), Instituto Universitário de Lisboa (ISCTE-IUL), Av. das Forças Armadas, 162...

A transient but considerable rise in serum creatine phosphokinase (CPK) levels occurred in six boys aged between 8 and 11 years and suffering from phenothiazine-induced dystonia. In one boy (Case 4), after the CPK level had returned to normal after withdrawal of the drug, its reintroduction orally at lower dosage caused a slight increase in the level of CPK in the absence of any recurrence of t...