Five women and 3 men (29.8 +/- 1.4 yr) performed dynamic knee-extension exercise inside a magnetic resonance system (means +/- SE). Two trials were performed 7-14 days apart, consisting of a 4- to 5-min exhaustive exercise bout. To determine quadriceps cost of contraction, brief static and dynamic contractions were performed pre- and postexercise. (31)P spectra were used to determine pH and rel...

The effect of creatine supplementation and sleep deprivation, with intermittent moderate-intensity exercise, on cognitive and psychomotor performance, mood state, effort and salivary concentrations of cortisol and melatonin were examined. Subjects were divided into a creatine supplementation group and a placebo group. They took 5 g of creatine monohydrate or a placebo, dependent on their group,...

To test the hypothesis that creatine supplementation would enhance the anabolic responses of muscle cell signaling and gene expression to exercise, we studied nine subjects who received either creatine or a placebo (maltodextrin) for 5 days in a double-blind fashion before undergoing muscle biopsies: at rest, immediately after exercise (10 x 10 repetitions of one-leg extension at 80% 1 repetiti...

Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (body mass index, 23 +/- 2 kg/m2, 21 +/- 1 yr, mea...

Abstract Introduction The benefit of creatine monohydrate supplementation in improving memory performance healthy humans is unclear. aim this study was to determine the effectiveness on humans. Method A literature search PubMed, Web Science, Cochrane Library, and Scopus for randomized clinical trials (RCTs) published from database inception until September 30, 2021, examining effects measures c...

Creatine, a nutritional supplement marketed to increase strength and muscle mass, is the most profitable performance-enhancing agent used among athletes today, grossing more than $200 million in 1998. As its use increases, especially among highschool athletes, the concern about its safety mounts. Because creatine is a dietary supplement, it is not regulated by the Food and Drug Administration, ...

To test the hypothesis that creatine supplementation would enhance the anabolic responses of muscle cell signalling and gene expression to exercise, we studied nine subjects who received either creatine or a placebo (maltodextrin) for 5d in a doubleblind fashion before undergoing muscle biopsies: at rest; immediately after exercise (10×10 repetitions of one leg-extension at 80% 1-RM); and 24h a...

BACKGROUND/AIMS Caffeine and creatine are 2 of the most widely available and used compounds in sport. Although the use of either is not considered a doping infraction, the evidence does suggest ergogenic potential in certain sports. The purpose of this paper is to review the pharmacology and potential mechanism(s) of action of caffeine and creatine as they pertain to possible use as an ergogeni...

In commercial production, chickens are subjected to feed withdrawal prior to slaughter and exposed to stress during transport and handling of the animals at the slaughterhouse; this causes plasma glucose and glycogen stores in liver and muscle to decrease, which has a negative impact on meat quality. The aim of the present study was to investigate how supplementation of the energy complements c...

I was particularly interested in the paper published in Cardiovascular Research (30, 413-418) by Gordon and co-workers entitled: Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. One of the objectives of their study was to evaluate the effects of creatine supplementation (20 g daily for 10 days) on ejection fraction in patient...