The adaptor protein Mig-6 is a negative regulator of EGF signaling. It is shown that Mig-6 inhibits cell migration via direct interaction with the ErbB receptors, thereby inhibiting cross-phosphorylation or targeting the receptors for degradation. Mig-6 has also been shown to bind to and inhibit the Rho GTPase Cdc42 to suppress cytoskeletal rearrangement. However, the molecular mechanism(s) by ...

The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory difficulty) attributable to hemodynamically-significant patent ductus arteriosus (hsPDA) at the time of first ...

OBJECTIVE To determine whether the use of sidecar cribs on the postnatal ward affects breastfeeding duration. DESIGN A randomised non-blinded parallel trial comparing sidecar cribs with standalone cots. SETTING Postnatal wards of the Royal Victoria Infirmary, Newcastle upon Tyne. PARTICIPANTS 1204 pregnant women intending to breastfeed were recruited at 20 weeks' gestation and randomised ...

Epithelial cells display apical-basal polarity, and the apical surface is segregated from the basolateral membranes by a barrier called the tight junction (TJ). TJs are constructed from transmembrane proteins that form cell-cell contacts-claudins, occludin, and junctional adhesion molecule (JAM)-plus peripheral proteins such as ZO-1. The Par proteins (partitioning-defective) Par3 and Par6, plus...

This paper assesses the feasibility of the maize storage structures used in Kenya. Maize is the most important staple crop, but produced seasonally, and consumed continuously at farm level, hence the need for on-farm storage. However, heavy post harvest losses occur mainly during harvesting and storage stages and these are a cost to the farmer. A cost benefit analysis was employed to evaluate t...

Objective : To identify which factors can predict INSURE failure in preterm infants with respiratory distress syndrome. Study design : A retropective analysis of the prenatal histories, clinical courses and paraclinical data of all inborn infants (birth weight < 2000g) with respiratory distress syndrome treated with INSURE method. Infants were categorized into 2 groups : "INSURE failure group" ...