Tail docking of feedlot cattle is a management practice used in some confined, slatted-floor feedlots of the midwestern United States. Justification for tail docking in these management systems is to reduce tail injuries and their sequelae and improve performance, but limited evidence exists to support these claims. The primary objective of this study was to determine the effect of tail docking...

Protein-protein interactions play a crucial role in biological processes. Protein docking calculations' goal is to predict, given two proteins of known structures, the associate conformation of the corresponding complex. Here, we present a new interactive protein docking system, Udock, that makes use of users' cognitive capabilities added up. In Udock, the users tackle simplified representation...

Motivation: Large-scale computational docking will be increasingly used in future years to discriminate protein–protein interactions at the residue resolution. Complete cross-docking experiments make in silico reconstruction of protein–protein interaction networks a feasible goal. They ask for efficient and accurate screening of the millions structural conformations issued by the calculations. ...

Syt1 (synaptotagmin 1), a major Ca2+ sensor for fast neurotransmitter release, contains tandem Ca2+-binding C2 domains (C2AB), a single transmembrane α-helix and a highly charged 60-residue-long linker in between. Using single-vesicle-docking and content-mixing assays we found that the linker region of Syt1 is essential for its two signature functions: Ca2+-independent vesicle docking and Ca2+-...

Recent years have witnessed a large amount of decentralized data in various (edge) devices end-users, while the aggregation remains complicated for machine learning jobs because regulations and laws. As practical approach to handling data, Federated Learning (FL) enables collaborative global model training without sharing sensitive raw data. The servers schedule within process FL. In contrast, ...

The structural modeling of protein-protein interactions is key in understanding how cell machineries cross-talk with each other. Molecular docking simulations provide efficient means to explore how two unbound protein structures interact. InterEvDock is a server for protein docking based on a free rigid-body docking strategy. A systematic rigid-body docking search is performed using the FRODOCK...