نتایج جستجو برای: cryptic
تعداد نتایج: 9824 فیلتر نتایج به سال:
The giant elastic protein titin is a determinant factor in how much blood fills the left ventricle during diastole and thus in the etiology of heart disease. Titin has been identified as a target of S-glutathionylation, an end product of the nitric-oxide-signaling cascade that increases cardiac muscle elasticity. However, it is unknown how S-glutathionylation may regulate the elasticity of titi...
Nascent secretory proteins are extensively scrutinized at the endoplasmic reticulum (ER). Various signatures of client proteins, including exposure of hydrophobic patches or unpaired sulfhydryls, are coordinately utilized to reduce nonnative proteins in the ER. We report here the cryptic N-glycosylation site as a recognition signal for unfolding of a natively nonglycosylated protein, transthyre...
Phylogenetic analysis using DNA sequence data from two nuclear genes was undertaken to investigate phylogeographic structure within the widespread leafmining pest Liriomyza huidobrensis (Blanchard). Parsimony analysis of 171 bp from b-tubulin (including an intron) and 921 bp from elongation factor-1a conÞrms previous Þndings from mitochondrial sequence data of deep phylogeographic structure ind...
Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17(+) simian immunodeficiency virus (SIV)mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8(+) T lymphocyte (CD8-TL) responses against a ...
Silencing of genomic regions in eukaryotes is thought to be the result of transcriptional repression. Recent results show that nuclear RNA degradation plays a major role in discarding RNA molecules with no obvious roles that are produced by cryptic RNA polymerase II transcription throughout the Saccharomyces cerevisiae genome. These cryptic transcripts are polyadenylated at their 3'-end by a po...
An abiding mystery in multiple myeloma (MM) has been the surprising heterogeneity in clinical outcome that characterizes this morphologically homogenous disease. For example, survival may be influenced by the immunoglobulin isotype expressed by MM cells. Similarly, some patients develop bone disease while others are spared. The genetic basis for both observations is obscure. Now, pioneering gen...
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