The metabolism of papaverine, the opium benzylisoquinoline alkaloid, with Aspergillus niger NRRL 322, Beauveria bassiana 22864, Cunninghamella echinulate ATCC 18968 and 1382 has resulted in O-demethylation, O-methylglucosylation N-oxidation products. Two new metabolites (4″-O-methyl-β-D-glucopyranosyl) 4′-demethyl papaverine 6-demethyl (Metabolites 5 6) together 4′-O-demethylated (Metabolite 1)...

A statistical design approach has been used to optimize the production of biomass by Cunninghamella sp. 2A1, evaluated based on lipidless biomass. A 2 3 full factorial central composite design (CCD) was chosen to study the combined effects of three factors; ammonium tartrate, peptone and glucose concentrations. The p-value for each factor was <0.05 suggesting that these factors have significant...

Chitosan the second most abundant polysaccharide is biodegradable, biocompatible, and nontoxic. These properties makes chitosan widely applicable in the pharmaceutical and biomedical fields for controlled release of drugs for wound management and space filling implants etc. In the present study fungal chitosan is isolated form Cunninghamella elegans, characterized by FT-IR spectroscopy by confi...

Many strains of zygomycetes and actinomycetes were found to convert milbemycin A4 (1a) to 13 beta-hydroxymilbemycin A4 (1b). Among these strains, Cunninghamella echinulata ATCC 9244 had the most efficient 13 beta-hydroxylation ability on milbemycins. In the conversion of milbemycin A3 (2a), 29-hydroxymilbemycin A4 (4a), and 30-hydroxymilbemycin A4 (5a) with this strain, only 13 beta-hydroxylate...