Nanos (Nos) has at least five different functions during the development of Drosophila melanogaster. In the pre-cellular blastoderm embryo, maternally derived Nos is required for formation of abdominal segments (Wang and Lehmann, 1991). Subsequently, maternal Nos is required in the embryonic germline precursors, the pole cells, to inhibit their division and promote migration into the somatic go...

OBJECTIVES After total hip arthroplasty (THA), restoration of hip center of rotation (COR) is essential to ensure stability of the prosthetic hip and longevity of the prosthesis. Our aim was to determine whether, and how, the COR changed postoperatively compared to the native COR following implantation of a cementless acetabular component in anatomical position and to compare the accuracy of cu...

BACKGROUND Concerns have been raised about the sequelae of metal-on-metal (MoM) bearings in total hip arthroplasty (THA). However, retrieval studies, which offer the best insight into the clinically relevant mechanisms of MoM wear, have followed predictable trends to date such as indicting cobalt-chromium (CoCr) metallurgy, cup design, high conformity between the head and cup, "steep cups," "mi...