BACKGROUND Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. PATIENTS AND METHODS Forty-one thousand five hundred and twenty-three CUP patient...

The introduction of new products has always been an important source economic development and improvement in consumer welfare. With retail coffee data spanning 5 years after the single-cup brew pods were introduced to grocery chains, this paper empirically studies market effects product brew-at-home market. We use a structural model demand supply capture changes consumers’ preference for over t...

With each isolating block for a homeomorphism of an orientable manifold we associate a cup product pairing. Up to an isomorphism, this is a pairing of the discrete Conley indices of the homeomorphism and its inverse on the isolating block. We show that this pairing is nondegenerate. As a corollary we prove a time duality result for the discrete Conley index. 0. Introduction The observation that...

This research is an expansion of the attitude toward green product model that has been tested in previous studies. examines effect perceived value, health benefits, consciousness, environmental attitude, value orientation and eWOM on attitudes products. Furthermore, impact continued products willingness to pay intention recommend was also tested, as well purchase intention. study seeks add gene...

Cancer of unknown primary site (CUP) is a fatal cancer diagnosed through metastases at various organs. Little is known about germline genetics of CUP which appears worth of a search in view of reported familial associations in CUP. In the present study, samples from CUP patients were identified from 2 Swedish biobanks and a German clinical trial, totaling 578 CUP patients and 7628 regionally ma...

Let X = C n. In this paper we present an algorithm that computes the cup product structure for the de Rham cohomology ring H dR (U; C) where U is the complement of an arbitrary Zariski-closed set Y in X. Our method relies on the fact that Tor is a balanced functor, a property which we make algorithmic, as well as a technique to extract explicit representatives of cohomology classes in a restric...

Navigation of the cup in total hip arthroplasty is well analyzed and shows accurate results, reducing cup outliers of Lewinnek's "safe zone." With regard to the combined anteversion of cup and stem, however, a "new" safe zone with a range of 25° to 50° has been published. The aim of this study was to analyze total anteversion (cup and stem) by postoperative 3D computed tomography in isolated cu...

In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for posterior patterning. This precision is accomplished by a localization-dependent translational control mechanism that ensures translation of only correctly localized oskar transcripts. Although progress has been made in identifying localization factors and translational repressors of oskar, none of ...

BACKGROUND Elevated waist circumference and body mass index (BMI), both traditional measures of obesity, are accepted risk factors for type 2 diabetes mellitus. Girls who are obese experience earlier onset of puberty and possibly greater breast development. We sought to evaluate whether a woman's breast size in late adolescence is associated with an increased risk of type 2 diabetes mellitus in...

Let GS be the Galois group of the maximal pro-p-extension QS of Q unramified outside a finite set S of places of Q not containing the prime p > 2. In this work, we develop a method to produce some examples of mild (and thus FAB) pro-p-group GS for which some relations are of degree 3 (according to the Zassenhaus filtration). The key computation are done in some Heisenberg extensions of Q of deg...