Dynamic hyperinflation is produced by a diffuse expiratory flow limitation impairing exhalation under mechanical ventilation. It constitutes a serious clinical problem in patients exhibiting bronchial asthma or chronic obstructive pulmonary disease, when mechanical ventilation is required. But this phenomenon may also complicate respiratory support in acute respiratory distress syndrome (ARDS) ...

We investigate the potential of strategic ship routing through dynamic currents derived from satellite altimetry by simulating current patterns in a dynamic Gulf Stream region to reflect present and improved current estimation capabilities, using dynamic programming to determine approximately 3-day routes through the current patterns, and estimating relative fuel savings that would be obtained ...

evidence provided from studies in iran points to a possible bias in application of the standard epi cluster sampling procedure, when carried out in populations with highly variant birth rates, tends to over-represent the low birth rate, i.e. higher socio-economic, strata, and if the entity under study shows significant socio-economic gradient, then the estimates arrived at by this method might ...

proteomics refers to the analysis of expression, localization, functions, posttranslational modifications, and interactions of proteins expressed by a genome at a specific condition and at a specific time. current proteomic tools allow large-scale, high-throughput analyses for the detection, identification, and functional investigation of proteome. in this review, we have focused on the proteom...

Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated.

BACKGROUND AND OBJECTIVE hearing impairment is common in older adults and has been implicated in the risk of disability and mortality. We examined the association between hearing impairment and risk of incident disability and all-cause mortality. DESIGN AND SETTING prospective cohort of community-dwelling older men aged 63-85 followed up for disability over 2 years and for all-cause mortality...

PURPOSE We compared the prevalence of disability among older American Indians and Alaska Natives (AI/ANs) with that among their African American and White peers, then examined sociodemographic characteristics associated with disability among AI/ANs. DESIGN AND METHODS We analyzed the 5% 2000 Census Public Use Microdata Sample. We assessed disability by functional limitation, mobility disabili...

OBJECTIVE To assess the construct and convergent validity of the 16 items of the Late-Life Disability Instrument (LLDI) in Latin American seniors. METHOD Exploratory and confirmatory factor analyses were performed to assess the factor structure of frequency and limitation sub-scales of the LLDI. ANOVA and t test were used to determine the convergent and construct validity of the LLDI by explo...