The revolution in molecular methods has allowed the development of approaches whereby cancer-specific changes can be utilised for targeted therapies. Gene therapy strategies include mutation compensation for correction of cancer-associated defects, and molecular chemotherapy for delivering toxic substances locally to tumour cells. Viruses which replicate only in tumour cells represent a powerfu...

Web services are defined independently of any execution context. Due to their inherent autonomy and heterogeneity, it is difficult to examine the behaviour of composite services, especially in case of failures. This paper is interested in ensuring composite services reliability. Reliable composition is defined as a composition where all instance executions are correct from a transactional and b...

Transport along axons and dendrites ranges from the fast movement of vesicles (50-500 mm day"), which can be observed directly by light microscopy, to the slow progress of cytoskeletal proteins. The latter, which has been followed only by using radiolabelled proteins (reviewed by Lasek et al. 1985), occurs at 0-2-8-0 mm day", but this is still faster than diffusion. The differential speeds of v...

STUDY OBJECTIVE To examine the relations between geographical variations in mortality, morbidity, and deprivation at the small area level in the south west of England and to assess whether these relations vary between urban and rural areas. DESIGN A geographically based cross sectional study using 1991 census data on premature limiting long term illness (LLTI) and socioeconomic characteristic...

Mass customisation is in contradiction with established manufacturing systems, which produce high quantities of identical parts. Even though products assembled according to individual customer demands are widely available in many areas, the shape of the individual parts of the assembled product is generally fixed. To enable mass customisation regarding the shape of these parts, new manufacturin...

BACKGROUND The antenatal detection of fetal growth restriction is a focus point of antenatal care. If detected fetal demise may be prevented and perinatal complications could be managed more appropriately. AIMS To investigate whether introducing serial plotting on customised fundal height charts can increase the detection rate of small for gestational age (SGA) fetuses in low risk nulliparous...

The paper presents a case study where the energy demand for a listed building constructed in 1900 is reduced. Many older buildings are listed and have restrictions that include the entire building or that include only its exterior. For the building presented, only its exterior facade is listed. The paper demonstrates measures for the improvement of the thermal insulation of the building with so...

We present a generic API suitable for provision of highly generic storage facilities that can be tailored to produce various individually customised storage infrastructures. The paper identifies a candidate set of minimal storage system building blocks, which are sufficiently simple to avoid encapsulating policy where it cannot be customised by applications, and composable to build highly flexi...