PURPOSE To compare the efficacy and side effects of loteprednol versus fluorometholone after myopic photorefractive keratectomy (PRK). METHODS One hundred and twenty four eyes of 62 patients who underwent PRK were enrolled in this study. One eye of each subject was randomized to receive loteprednol 0.5% and the fellow eye was given fluorometholone 0.1%. Patients were followed up for three mon...

AIM To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). METHODS Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg alpha tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 da...

Photorefractive keratectomy (PRK) remodels corneal stroma to compensate refractive errors. The removal of epithelium and the ablation of stroma provoke the disruption of corneal nerves and a release of several peptides from tears, epithelium, stroma and nerves. A myriad of cytokines, growth factors, and matrix metalloproteases participate in the process of corneal wound healing. Their balance w...

PURPOSE To report the use of photorefractive keratectomy (PRK) with mitomycin-C (MMC) to treat concomitant myopia and visually significant infiltrates associated with epidemic keratoconjunctivitis (EKC). SETTING Ophthalmic Consultants of Long Island, Nassau University, Long Island, New York, USA. DESIGN Interventional case series. METHODS Consecutive patients with myopia and recalcitrant ...

PURPOSE To assess the effects of topical corticosteroids (fluoromethalone) following photorefractive keratectomy (PRK). METHODS Both eyes of 654 patients had PRK with a minimum of 4 months between treatments. Topical corticosteroids were prescribed for one eye only. Endpoints were assessed by comparing the ratio of intended to actual refractive change in the corticosteroid treated eye with th...

PRK AND ROCK ARE REQUIRED FOR THROMBIN-INDUCED ENDOTHELIAL CELL PERMEABILITY DOWNSTREAM FROM Gα12/13 and Gα11/q Julie Gavard and J Silvio Gutkind From 1 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 Running head: RhoA bifurcation on ROCK and PRK *Address correspondance to: Julie Gavard, Ph.D., C...

purpose: to compare tear secretion values following lasik (laser in situ keratomileusis) and photorefractive keratectomy (prk). methods: patients referred to aban eye clinic (isfahan, iran) for refractive surgery were randomly assigned to lasik or prk. exclusion criteria were contraindications for refractive surgery, usage of topical ocular drugs, dry eye and reoperation. schirmer test was perf...

PURPOSE To assess the contribution of corneal myofibroblasts to optical changes induced by photorefractive keratectomy (PRK) in a cat model. METHODS The transforming growth factor (TGF)-beta-dependence of feline corneal keratocyte differentiation into alpha-smooth muscle actin (alphaSMA)-positive myofibroblasts was first tested in vitro. Twenty-nine eyes of 16 cats were then treated with -10 ...