Drug hypersensitivity reactions affect many patients leading to a variety of clinical manifestations, mainly the cutaneous adverse reactions ranging from milder skin reactions to severe cutaneous adverse reactions (SCARs). Hypersensitivity reactions are unpredictable and are thought to have an underlying genetic etiology, as suggested by case reports. With the scientific knowledge of pharmacoge...

INTRODUCTION In spite of growing concern of routine mechanotherapy modalities in patients' health and recent regulations on nickel exposure, there has been no relevant meta-analysis. The aim of this study, therefore, was to investigate the effect of orthodontic therapy on the prevalence of nickel hypersensitivity and compare it with the prevalence in the general population. METHODS Several el...

OBJECTIVE To study the diagnostic and treatment modalities used in drug allergy/hypersensitivity among members of the World Allergy Organization (WAO). METHODS A questionnaire comprising 39 questions was circulated electronically to member societies, associate member societies, and regional and affiliate organizations of WAO between June 29, 2009, and August 9, 2009. RESULTS Eighty-two resp...

The presence of anergy and its relationship to malnutrition was investigated in patients with rheumatoid arthritis (RA) and in controls. A generalised reduction in delayed cutaneous hypersensitivity to 7 recall antigens were found in 104 RA patients compared with 67 controls. No measured of the disease was capable of predicting cutaneous anergy, which was present in 36% of patients but none of ...

Twenty-eight patients with chronic renal diseases and uremia were investigated with respect to their cutaneous responsiveness to a panel of antigens expected to elicit immediate and delayed hypersensitivity reactions. Compared to a control group, there was a marked decrease in the incidence of responses of both types. Eighteen patients received renal allografts from members of the control group...

The clinical features and cutaneous hypersensitivity to skin prick tests were studied in 64 asthmatic patients in General Hospital, Kandy (Sri Lanka). The onset of asthma was mostly in adult life; associated atopic disease and family history of allergy were less frequent when compared with asthmatics in industrialised countries in the temperate zone. In these respects the clinical pattern of as...

The effect of weight loss on immuno function was evaluated in 14 middle-aged obese women. Cutaneous delayed-type hypersensitivity to five recall antigens was measured before a weight loss of 21 kg and again after weight had been stabilized. Weight loss was associated with a decrease in both number and magnitude of delayed-type hypersensitivity responses. The number of positive skin tests decrea...

India has the highest burden of tuberculosis (TB) in the world and cutaneous TB accounts for about 1.5% of extrapulmonary disease [1,2]. It is seen in greater frequency with HIV infection, which is also rampant there [1,3]. Skin lesions could be either “true” cutaneous TB (lupus vulgaris, TB verrucosa cutis, scrofuloderma, orificial TB, military TB) or tuberculids [4]. The latter are believed t...