Localized and multisystem nocardiosis is an opportunistic disease that occurs commonly in immunocompromised patients. Rarely, it is also seen in immunocompetent individuals. The most common disease sites include lung, skin and central nervous system. We report a case of 73 years old man who is a known case of rheumatoid arthritis for more than 15 years and was on Methotrexate and Prednisolone. ...

© 2017 Advanced Biomedical Research | Published by Wolters Kluwer Medknow Sir, Shirani et al. recently reported an article entitled, “Nocardial brain abscess in a patient with pulmonary alveolar proteinosis” (DOI: 10.4103/2277-9175.164004).[1] The genus Nocardia is a Gram-positive aerobic, partially acid-fast, and fi lamentous bacterium that causes nocardial infections (nocardiosis) in human. T...

The patient was a 71-year-old man. Two months after using prednisolone at a dose of 80 mg/day for the treatment of drug-induced interstitial pneumonia induced by chemotherapy following lung cancer surgery, his chest x-ray fi lm showed cavitary shadows, and Nocardia farcinica was detected from subcutaneous abscess, sputum, urine, and blood cultures. Thus, disseminated nocardiosis involving multi...

Nocardiosis is an uncommon bacterial gram-positive infection caused by aerobic actinomycetes in the genus Nocardia. Nocardiosis is typically regarded as an opportunistic infection with approximately two-thirds of infected patients being immunocompromised. In this case report we describe a 45-year-old female who presented with a right thigh abscess. She had been taking high-dose prednisolone and...

A novel therapeutic approach for Nocardia infections is presented. We report the successful treatment of lymphocutaneous nocardiosis with a three-drug combination in an immunocompromised patient with in vitro susceptibility testing used to guide therapy. New therapeutic options are required in some patients due to their failure to respond to the treatment of choice, trimethoprim-sulfamethoxazol...

Nocardiosis is an uncommon infection that occurs primarily in the immunocompromised patients, especially in patients with defective cell-mediated immunity [2]. Less commonly it may also be encountered in immunocompetent hosts. However, its incidence is rising probably due to the advent of improved and advanced laboratory detection methods and also due to the growing number of immunosuppressed p...

a b s t r a c t a few case reports of coinfections with nocardia and mycobacterium tuberculosis (tb) have previously been published in the literature. we report on a case of concomitant pulmonary nocardiosis and tuberculosis, in a recently diagnosed 55-year-old woman, with rheumatoid arthritis, who had been taking a short course of a low dose corticosteroid. the patient was treated with a combi...

Infliximab is a chimeric anti-tumour necrosis factor-alpha antibody that is efficacious in treating Crohn's disease. However, its immunomodulatory properties increase susceptibility to opportunistic infections. We present a case of cutaneous Nocardia infection in a patient who was taking infliximab for Crohn's disease. The case illustrates the challenges in the diagnosis and management of this ...