Clearly, high throughput omics, and related technologies, are advancing quickly. So too are the many challenges to efficient analysis and interpretation of data generated. This issue presents cutting edge research and unmet translational needs related to these challenges. Marcus, et al., address the scarcity of standardized sequencing procedures, data formats and quality management in ‘Standard...

Successful revascularisation of chronic total occlusions (CTOs) remains one of the greatest challenges in the era of contemporary percutaneous coronary intervention (PCI). Such lesions are encountered with increasing frequency in current clinical practice. A predictable increase in the future burden of CTO management can be anticipated given the ageing population, increased rates of renal failu...

The max-cut problem and the associated cut polytope on complete graphs have been extensively studied over the last 25 years. However, little research has been conducted for the cut polytope on arbitrary graphs. In this study we describe new separation and lifting procedures for the cut polytope on such graphs. These procedures exploit algorithmic and structural results known for the cut polytop...

We propose a branch and cut algorithm for the Pallet Loading Problem. The 0-1 formulation proposed by Beasley for cutting problems is adapted to the problem, adding new constraints and new procedures for variable reduction. We then take advantage of the relationship between this problem and the maximum independent set problem to use the partial linear description of its associated polyhedron. F...

The management of wound exudate requires the clinician to have an understanding of what it is, why it is present and how to monitor and assess it accurately (White and Cutting, 2006). Wound exudate was described as nature’s balsam many years ago (White and Cutting, 2006) and is the fluid produced by an open wound. It is derived from fluid that has leaked from capillaries into body tissues (Worl...

Experimentation with the selection silvicultural system in the Engelmann Spruce-Subalpine Fir (ESSF) Zone of east-central British Columbia began nearly ten years ago. The initial impetus for partial cutting came from concerns about specific nontimber resources, such as scenic values, water quality for domestic use, and habitat for mountain caribou (Rangifer tarandus). A set of first-generation ...

Separation of concerns has long been considered an effective and efficient strategy to deal with complexity in information systems. One sort of concern crosses over other concerns, which makes their management difficult. Aspect Orientation is a paradigm in information systems which aims to encapsulate cross-cutting concerns to overcome this problem. In the Business Process Management (BPM) area...