Identifying the conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the function of the tumor suppressor gene. In this study, expression of BRCA2 mRNA is shown to be regulated by the cell cycle and associated with proliferation in normal and tumor-derived breast epithelial cells. Cells arrested in G(0) or early G1 contained low levels of BRCA2 mRNA. After r...

tion at the end of each case. For students desiring a more in-depth review, the analysis section of each case provides a great and more detailed overview. An extra index organized by disorder name in the back also allows the reader to focus on particular aspects of internal medicine. Details such as this make it obvious that the authors have tried to cater to the varying needs of their readers,...

This paper considers a limit cycle control problem of a multi-modal and 2-dimensional piecewise affine control system. Limit cycle control means a controller design method to generate a limit cycle for given piecewise affine control systems. First, we deal with a limit cycle synthesis problem and derive a new solution of the problem. In addition, theoretical analysis on the rotational direction...

The cell division cycle of the early sea urchin embryo is basic. Nonetheless, it has control points in common with the yeast and mammalian cell cycles, at START, mitosis ENTRY and mitosis EXIT. Progression through each control point in sea urchins is triggered by transient increases in intracellular free calcium. The Cai transients control cell cycle progression by translational and post-transl...

In intact animals and humans, increases in locomotor speed are usually associated with decreases in step cycle duration. Most data indicate that the locomotor central pattern generator (CPG) shortens cycle duration mainly by shortening the durations of extensor rather than flexor phases of the step cycle. Here we report that in fictive locomotion elicited by electrical stimulation of the midbra...

Cancer is a multifaceted disease, but a common feature of most tumours is that they harbour one or more genetic mutations that allow them to proliferate outside their normal growth restraints. Proliferation is normally restrained through control of the cell division cycle, which in turn, is regulated by the Cdk family of serine/threonine kinases and their regulatory partners the cyclins. Here, ...