A patient with well documented cyclic neutropenia (CN) was given chronic lithium therapy as well as a short course of plasmapheresis with therapeutic intention. While on lithium therapy. an increase in the amplitude of the granulocyte oscillations was observed. but recurrent agranulocytotic periods persisted. A 2-wk course of plasmapheresis (total exchange 1 7 liters) resulted in a gradual decr...

Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were r...

the velocity sedimentation of DNA prepared 4 hr after administration of from 1to 100mg/kg body weight nitroso morpholine were observed in both alkaline and neutral su crose gradients. The single-strand damage to DNA was not completely repaired 14 days after treatment while the double-strand breaks were more rapidly repaired. Injec tion of similar doses of either of the other two cyclic com poun...

The inhibition of aggregation of rat platelets treated with betaadrenoceptor blocking drugs alprenolol, exaprolol, metipranolol, practolol and propranolol, and stimulated with adenosinediphosphate was shown to be dose-dependent. Atenolol in all concentrations potentiated the aggregation. The stimulated aggregation was potentiated by low and decreased by high concentrations of doberol. Cyclic ad...

OBJECTIVE Cyclic mastalgia is described as a diffuse, periodic and bilateral breast pain that can not be localized. Although there are several methods of treatment, the most efficient treatment method is still controversial. The aim of this study is to determine, compare and discuss the results of the patients under 40 years old age with a complaint of cyclic mastalgia and without any clinical ...

abstract objective fever and neutropenia are a common complication of chemotherapy in cancer. it is usually managed by hospitalization and empiric administration of antibiotics. use of fluroquinolones is limited because of joint/cartilage toxicity. this study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia....

Clinical effects of purified human urinary colony-stimulating factor (CSFHU) were studied in nine patients with chronic neutropenia of childhood who ranged in age from 1 to 18 years. The patients were given CSFHU at a dose of 6 x 10(6) U/m2/d for seven consecutive days, and their peripheral neutrophil counts were serially followed for 6 to 12 months. In addition, changes in bone marrow morpholo...

Patients with idiopathic, cyclic, and congenital neutropenia have recurrent severe bacterial infections. One hundred twenty-three patients with recurrent infections and severe chronic neutropenia (absolute neutrophil count < 0.5 x 10(9)/L) due to these diseases were enrolled in this multicenter phase III trial. They were randomized to either immediately beginning recombinant human granulocyte c...