Learning about motivationally important stimuli involves plasticity in the amygdala, a temporal lobe structure. Amygdala-dependent learning involves a growing number of plasticity-related signaling pathways also implicated in brain development, suggesting that learning-related signaling in juveniles may simultaneously influence development. Here, we review the pleiotropic functions in nervous s...

Abstract Additively manufactured specimens generally exhibit comparable or improved tensile properties, such as yield stress, ultimate strength, and uniform elongation, compared to conventionally specimens. However, the defects that are typically present in additively microstructures result inferior fatigue performance. A representative volume element-based modeling technique incorporating thes...

A common belief in phenomenological strain gradient plasticity modeling is that including the of scalar variables constitutive setting leads to size-dependent isotropic hardening, whereas second-order tensors induces kinematic hardening. The present paper shows it also possible produce hardening using scalar-based theory. For this purpose, a new model involving equivalent plastic developed and ...

When subjected to a monotonically increasing deformation state, the mechanical behavior of UHMWPE is characterized by a linear elastic response followed by distributed yielding and strain hardening at large deformations. During the unloading phases of an applied cyclic deformation process, the response is characterized by nonlinear recovery driven by the release of stored internal energy. A num...

Hydride formation in Zircaloy-4 under cyclic thermomechanical loading has been investigated using characterized notched beam samples four-point testing, and microstructurally-representative crystal plasticity modelling of the tests which incorporates an atomistically-informed equilibrium-state model for hydrogen concentration. The provided locations within microstructure high content, above tha...

A thermodynamics-based damage mechanics rate dependent constitutive model is used to simulate experiments conducted on thin layer eutectic Pb/Sn solder joints. As compared to previous implementations of the model here we correct the difficulties introduced by the slow convergency rate of the Owen and Hinton (Owen, D.R.J., Hinton, E., 1980. Finite Element in Plasticity. Pineridge Press Limited, ...

In this paper, a fully variational constitutive model of soft biological tissues is formulated in the finite strain regime. The model includes Ogden-type hyperelasticity, finite viscosity, deviatoric and volumetric plasticity, rate and microinertia effects. Variational updates are obtained via time discretization and pre-minimization of a suitable objective function with respect to internal var...

27 The synaptic plasticity literature has focused on establishing necessity and sufficiency as 28 two essential and distinct features in causally relating a signaling molecule to plasticity 29 induction, an approach that has been surprisingly lacking in the intrinsic plasticity 30 literature. Here, we complemented the recently established necessity of inositol 31 trisphosphate (InsP 3) receptor...

The synaptic plasticity literature has focused on establishing necessity and sufficiency as two essential and distinct features in causally relating a signaling molecule to plasticity induction, an approach that has been surprisingly lacking in the intrinsic plasticity literature. In this study, we complemented the recently established necessity of inositol trisphosphate (InsP3) receptors (InsP...