Abstract The purpose of this study was to explore the inhibitory effect α-methyl-5- hydroxytryptamine (α-methyl-5-HT) on ATP-activated current (IATP) in rat dorsal root ganglion (DRG) neurons. Whole-cell patch clamp experiment performed cultured DRG One minute after treatment with α-methyl-5-HT, ATP (10-4 mol/L) activation neurons inhibited. However, independent caused by α-methyl-5-HT. dose-re...

Objective: Crinum jagus is used in traditional African medicine the treatment of epilepsy, pain and inflammations.
 Methods: Anticonvulsant activity was investigated using picrotoxin (PCT) strychnine (STR) tests experimental paradigm.
 Results: leaf methanol extract (200, 400, 800 mg kg−1) potentiated hexobarbitone-induced sleeping time significantly (p<0.05) shortened duration con...

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter ...

This study was undertaken to examine the response to ergonovine, an agent used to provoke spastic constriction of large epicardial coronary arteries, to elucidate the responsible underlying mechanism, and to determine the impact of endogenous hyperlipidemia on contractile properties of isolated vessels from different beds. The isolated arteries from both control and Watanabe hereditary hyperlip...

Sensitive, accurate and precise methods for the qauantitative determination of Seven drugs viz., Cyclobenzaprine HCl (CYC), Cyproheptadine HCl (CYP), Dobutamine HCl (DOB), Moxifloxacin HCl (MOX), Pamiprioxole HCl (PAM), Sumatriptan succinate (SUM) and Trimetazadine 2HCl(TRI) haave been developed . The methods are based on the charge transfer interqction of iodine with drugs which resulted in th...

The clinical features and risk of hepatotoxicity of 'Sleep-Qik' (valerian dry extract 75 mg, hyoscine hydrobromide 0.25 mg, cyproheptadine hydrochloride 2 mg) were determined in 23 patients treated in our hospital between 1988 and 1991. The main clinical problems were central nervous system depression and anticholinergic poisoning. There was no clinical evidence of acute hepatitis in the 23 pat...

The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with...