Retinoids exhibit chemotherapeutic and chemopreventive activities, possibly due to their ability to modulate cell growth, differentiation, and apoptosis. These effects are thought to be mediated by nuclear retinoic acid (RA) receptors (RARs) and retinoid X receptors, each of which includes three subtypes (alpha, beta, and gamma) that act as transcription factors. To determine whether RARs play ...

Scientific high-end computing (HEC) has become an important tool for scientists world-wide to understand problems, such as in nuclear fusion, human genomics and nanotechnology. Every year, new HEC systems emerge on the market with better performance and higher scale. With only very few exceptions, the overall availability of recently installed systems has been lower in comparison to the same de...

Human-elephant conflict (HEC) threatens the survival of endangered Asian elephants (Elephas maximus). Translocating "problem-elephants" is an important HEC mitigation and elephant conservation strategy across elephant range, with hundreds translocated annually. In the first comprehensive assessment of elephant translocation, we monitored 16 translocations in Sri Lanka with GPS collars. All tran...

The role, effectiveness, and even existence of hospital ethics committees (HECs) are not universally agreed upon. Over the past 20 years, the study of HECs has focused mainly on their structure, scope, and function, making the results more descriptive than anything. In an effort to present study results that could help HECs better serve the needs of their organizations, the authors of this arti...

This paper presents a modeling application of surface runoff using the Hydrologic Modelling System (HEC-HMS). A case study was carried out for the Jianghe watershed, a typical semi-arid and sub-humid geo-climatic region in northern China. Two modeling schemes using different descriptive sub-mechanism models provided by HEC-HMS for runoff volume, direct runoff and routing (channel flow) were inv...

Extreme hydro-meteorological phenomena have become more frequent in recent years compared to the year 2000 Europe, including Romania. Flooding occurs from heavy rainfalls favored by natural and anthropogenic factors such as valley’s flat slope or settlements situated near river. Ţigăneşti Brânceni villages (from southern Romania) are no exception been affected floods many times. One of these ev...

Rivers play an essential role to humans and ecosystems, but they also burst their banks during floods, often causing extensive damage crop, property, loss of lives. This paper characterizes the 2014 flood Indus River in Pakistan using US Army Corps Engineers Hydrologic Engineering Centre Analysis System (HEC-RAS) model, integrated into a geographic information system (GIS) satellite images from...

BACKGROUND Radiation therapy is a well-recognized, effective modality used for palliative care. Most studies completed to date have endpoints of one month or greater after treatment completion. This study analyzed the response rates at different time points during the first month after treatment. METHODS From May 2010 to November 2011, 61 patients treated for 74 metastases were included in th...