Current studies on the fatigue lifetime of ceramics are mostly focused on the relation between the stress amplitude (or maximum stress) and cycles to failure. For a more compliant and plastic ceramic which has a pronounced nonlinear stress-strain relation, the role of plastic strain in the fatigue damage is investigated for the first time in this study using a 12 mol% Ce-TZP. By testing at diff...

Our recent studies show that chronic oral nicotine partially protects against striatal damage in 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP)-treated nonhuman primates. To identify the cellular changes associated with this protective action, we investigated the effects of nicotine treatment on stimulus-evoked dopamine release, dopamine turnover, and synaptic plasticity in striatum from le...

We model experience-dependent plasticity in the adult rat S1 cortical representation of the whiskers (the barrel cortex) which has been produced by trimming all whiskers on one side of the snout except two. This manipulation alters the pattern of afferent sensory activity while avoiding any direct nerve damage. Our simplified model circuitry represents multiple cortical layers and inhibitory ne...

Multiple sclerosis is an autoimmune neurodegenerative disorder resulting in motor dysfunction and cognitive decline. The inflammatory and neurodegenerative changes seen in the brains of MS patients lead to progressive disability and increasing brain atrophy. The most common type of MS is characterized by episodes of clinical exacerbations and remissions. This suggests the presence of compensati...

Abstract In this paper, the parameters optimization of a tuned mass damper (TMD) is presented to enhance seismic performance six-story steel structure based on ductility damage index. Herein, frame modeled nonlinearly in OpenSees software by concentrated plasticity model. Finally, most suitable algorithm selected among several algorithms convergence rate and objective function's values. process...

The applicability of both prediction methods for low-cycle fatigue life powder superalloy based on the Manson-Coffin equation and damage mechanics were addressed. Both models evaluated by experimental data FGH96 with non-destructive standard parts those inclusions. Due to characteristics high strength low plasticity FGH96, errors in calculating plastic strain amplitude deviate severely outcomes...

This article is a review of models for predicting ultra-low cycle fatigue life. In the article, life prediction are divided into three types: (1) microscopic ductile fracture based on cavity growth and merger; (2) porous plasticity; (3) continuum damage mechanics. Furthermore, provides critical assessment current state research models, highlighting limitations challenges faced by each model typ...