the present study was carried out for evaluation of calcoflour white staining (cws) as a rapid method for detection of pneumocystis carinii in respiratory specimens of rats as an animal model for human infection. a total of 35 spraque – dawley rats were divided into two groups. group1 (20 rats) received increasing doses of dexamethasone subcutaneously, and group 2(15 rats)as control group that ...

A variety of antibiotic and chemotherapeutic agents were tested for their ability to inhibit the development of dental caries in Sprague-Dawley rats receiving the drugs in a coarse-particle sucrose-containing diet. Drugs which inhibit gram-positive microorganisms were effective inhibitors of caries, whereas agents which are active solely against gram-negative bacteria did not inhibit caries dev...

Altered pain responding in depression is a widely recognized but poorly understood phenomenon. The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious stimuli in two animal models of depression, the olfactory bulbectomized (OB) and the Wistar-Kyoto (WKY) rat. In addition, this study examined if altered nociceptive behaviour w...

The Dahl salt-sensitive rat (SS/Jr) is a widely used animal model of salt-sensitive hypertension. SS/Jr rats are believed to be highly inbred and uniformly sensitive to the hypertensinogenic effects of sodium chloride, but we have recently observed that SS/Jr rats from Harlan Sprague Dawley, Inc, exhibit considerable variability in their blood pressure response to supplemental dietary salt. To ...

Several factors which affect the sensitivity of calcitonin bioassay were investigated. As to the assay animals, Sprague-Dawley and Holtzman rats were more sensitive than Wistar rats. In mice, C3H III strain gave better response to calcitonin than CF 1 and ddN strains. In each strain, younger rats were more sensitive than older ones. It was also demonstrated that the longer was the period of low...

Purpose: To investigate the inhibitory effect of strontium ranelate on alveolar bone resorption in diabetic rats with periodontitis, and mechanism involved.Methods: Forty-five Sprague-Dawley (SD) were allocated to 3 groups, viz, control, periodontitis + groups. Diabetes was induced via i.v. administration streptozotocin (STZ) (45 mg/kg). Then, a rat model established by ligating neck upper left...

Purpose: To exaluate the effect of perfluorocarbon on lung ischemia-reperfusion injury in rats, and to unravel potential underlying mechanism.Methods: A total 36 Sprague-Dawley (SD) rats were randomly assigned sham group, model group (12 per group). The levels inflammatory factors (TNF-α IL1β) determined using enzyme-linked immunosorbent assay (ELISA). Cell apoptosis was evaluated by terminal d...

It has been reported that twice-weekly i.p. injections of 4 mg phorbol for 10 weeks, after a single feeding of 6 mg dimethylbenz(a)anthracene (DMBA) in female Wistar rats, led to a significant augmentation of mammary adenocarcinoma incidence and of lymphatic leukemia incidence as compared to 6 mg DMBA alone. In an experiment reported here, in female Sprague-Dawley rats, using the same doses of ...

Studies with angiotensin (Ang) II type 1 receptor blockers suggest that the brain renin-angiotensin system contributes to sodium-induced sympathoexcitation and hypertension. To provide more specific evidence for the involvement of Ang II, locally produced in the brain, transgenic rats were used, which express an antisense RNA against angiotensinogen mRNA specifically in the brain, reducing angi...

A physiologically based pharmacodynamic (PBPK) model for 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was developed based on pharmacokinetic data from acute oral exposures of TCDD to female Sprague-Dawley rats (Wang et al., 1997, Toxicol Appl. Pharmacol 147, 151-168). In the present study, the utility of this model to predict the disposition of TCDD in male and female Sprague-Dawley and female W...