In protein redesign one of the main challenges is the ability to evaluate many different conformations of the redesigned protein in order to determine the best structure. One approach to this problem is to provably get rid of bad protein conformations using dead-end elimination (DEE). DEE was first developed for application to protein structure evaluation by Desmet et al. [1]. Since then there ...

Fusion of cellular membranes during normal biological processes, including proliferation, or synaptic transmission, is mediated and controlled by sophisticated protein machinery ensuring the preservation of the vital barrier function of the membrane throughout the process. Fusion of virus particles with host cell membranes is more sparingly arranged and often mediated by a single fusion protein...

Recent techniques for inferring business relationships between ASs [1, 2] have yielded maps that have extremely few invalid BGP paths in the terminology of Gao [3]. However, some relationships inferred by these newer algorithms are incorrect, leading to the deduction of unrealistic AS hierarchies. We investigate this problem and discover what causes it. Having obtained such insight, we generali...

Critics of sexual conflict theory argue that females may gain a net reproductive benefit from mating with manipulative males because the direct costs that they suffer may be offset by the production of sexy, i.e. manipulative, sons. However, this exclusive focus on nuclear gene effects represents an incomplete view of female fitness. Females differ fundamentally from males in transmitting not o...