A 10-year-old Malay girl with underlying HbE/beta-thalassemia, on regular blood transfusion and deferoxamine iron chelation therapy, presented two-month history of bilateral blurring vision. On examination, her vision was 6/36 both eyes. Other optic nerve functions were normal. Anterior segment examination eyes unremarkable. Fundus revealed dull foveal reflex. Optical coherence tomography macul...

We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indicating a different mode of action. Penetration was demonstrated by showing DFO...

Fulminant hepatic failure is a fatal complication of iron intoxication. Currently, there no well-established treatment. A 23-year-old Japanese woman, with past medical history deficiency anemia, presented fulminant caused by Multiple organ progressed despite plasma exchanges and deferoxamine therapy, she subsequently developed acute respiratory distress syndrome. Even though Venous-Venous Extra...

the disease of thalassemia major requires mangement by repeated transfusions of packed cell and iron chelators such as deferoxamine. today, serum ferritin is used for estimation of adequacy of the management. as the most morbidities and mortalities of the disease are the consequences of cardiac complications. echocardiography is periodically periodically performed along with the management. in ...