mannose-binding lectin (mbl) is a protein of innate immune system that is involved in opsonization and complement activation. mbl deficiency is associated with predisposition to infectious diseases; however subnormal levels are also seen in healthy subjects. the aim of this study was to investigate the prevalence and clinical manifestation of mbl deficiency in patients with increased susceptibi...

introduction: normal homeostasis system has several inhibitor mechanisms in front of the amplifier’s natural clotting enzyme to prevent fibrin clots in the vessels. the main inhibitors of coagulation pathway are antithrombin (at), protein c and protein s. patients with hereditary deficiency of coagulation inhibitors are susceptible to venous thromboembolism (vte). one of the major clinical mani...

this review summarizes current data on the pathomechanisms and new genetic findings of combined factor v and viii deficiency (cf5f8d). congenital haemorrhagic disorders characterized by deficiency of two clotting factors comprise an interesting group. among dual coagulation disorders, cf5f8d is the most common type. for the first time combined factor v and viii deficiency (f5f8d) was reported b...

zinc is one of the elements necessary for growth and health in human. some evidences indicate that the zinc deficiency is one of real difficulties for the public health in developed and developing countries. since the pregnant women are more at risk by the zinc deficiency, and this can cause many problems, in this study we tried to find out the rate of zinc deficiency in pregnant women within t...

Considering the COVID-19 pandemic, vitamin D is a target of research and speculation. Lockdown or home isolation reduces sunlight exposition increases risk deficiency. Special attention needed for older people at both severe forms This review aims to highlight association in two instances, direct influence on immune system, indirect risks other deficiency-related diseases, such as musculoskelet...

Congenital factor X deficiency is a rare autosomal recessive bleeding disorder that presents with variable bleeding tendency and prolonged coagulation tests, prothrombin time, and partial thromboplastin time. Thromboembolic events have not been reported in patients with factor X deficiency yet. Herein, we report a patient with factor X deficiency who had recurrent venous thromboembolic events.

background: the prevalence of vitamin d deficiency and its causative factors has been estimated more frequently in elder popula­tion, women, and patients with osteoporosis in different countries, but this issue is less defined in male population within different age groups especially in asian countries. therefore, we studied the role of effective factors in vitamin d defi­ciency and its prevale...

objective data on the relationship between iron deficiency anemia and febrile convulsions are controversial. the aim of this study was to determine the association between iron deficiency anemia and febrile convulsions among children. materials & methods this case-control study was conducted during 2006-2007, on 90 children with febrile seizures (case) and 90 febrile children without seizures (...

autism is a neurodevelopmental disorder, characterized by poor social interaction and communication impairment and repetitive behavior. autism is considered as a genetic and multifactorial disorder, with diverse risk factors involved. herein, we report a 13-year-old male with common variable immunodeficiency (cvid), who was diagnosed with autism at the age of 3 years old. as  there  are  some  ...