BACKGROUND Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we investigated the osteogenic effect of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA; vorinostat). METHODS The effects of SAHA on osteoblast di...

Discovery of new antifungal chemo-therapeutics for humans is limited by the large degree of conservation among eukaryotic organisms. In recent years, the histone acetyl-transferase Rtt109 was identified as the sole enzyme responsible for an abundant and important histone modification, histone H3 lysine 56 (H3K56) acetylation. In the absence of Rtt109, the lack of acetylated H3K56 renders yeast ...

Acetylation is a well-established process to improve dimensional properties of wood and resistance fungi attack. This study was carried out due limited studies on the effect acetylation mechanical properties, thermal stability, microstructural aspects wood. Wood blocks, (each 20×20×60 mm) Obeche were acetylated with acetic anhydride at 120 °C for 60, 120, 180, 240 300 minutes. The microstructur...

A classic example of chromosome elimination and genomic imprinting is found in sciarid flies (Diptera. Sciaridae), where whole chromosomes of exclusively paternal origin are discarded from the genome at different developmental stages. Two types of chromosome elimination event occur in the germline. In embryos of both sexes, the extrusion of a single paternal X chromosome occurs in early germ nu...

The cardiac insulin-like growth factor 2 receptor (IGF-2R) can induce cardiomyocyte hypertrophy in a heterotrimeric G protein receptor-coupled manner involving αq (Gαq) or αs (Gαs). We have previously shown increased left ventricular weight and cardiac IGF-2 and IGF-2R gene expression in low-birth-weight (LBW) compared with average-birth-weight (ABW) lambs. Here, we have investigated the cardia...

The esterification of galacturonic acid with methanol and/or acetic is important for the structural analysis pectin. Although several methods have been reported determining degree methylesterification (DM) and acetylation (DAc), present study compares optimizes three (titration, FT-IR HPLC) using commercial citrus pectin (CP). Our results showed that DM CP was 47.0%, 47.6% 48.0% as determined b...

A wholly bio-composite based on poly (lactic acid) (PLA) and tannin acetate was successfully prepared via in situ reactive extrusion using dicumyl peroxide (DCP) to improve interfacial adhesion. The composites PLA with high acetylation degree exhibited increased molecular weight as compared extruded PLA, together the improvement of Young’s modulus tensile strength. rheology results showed that ...

compare the effect of different ceramic thicknesses on degree of conversion (dc) of 3 light-cured resin cements. methods: in this experimental in-vitro study, the degree of conversion of three light-cured resin cements, variolink veneer (ivoclar, liechtenstein), relyx veneer (3m espe, usa) and choice2 (bisco, usa) were evaluated beneath feldespatic ceramic discs (vita vmk master) with a same sh...

statement of problem: for many years, application of the composite restoration with a thickness less than 2 mm for achieving the minimum polymerization contraction and stress has been accepted as a principle. but through the recent development in dental material a group of resin based composites (rbcs) called bulk fill is introduced whose producers claim the possibility of achieving a good rest...