introduction h istone deacetylase inhibitors (hdis), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...

Fear memories typically persist for long time periods, and persistent fear memories contribute to post-traumatic stress disorder. However, little is known about the cellular and synaptic mechanisms that perpetuate long-term memories. Here, we find that mouse hippocampal CA1 neurons exhibit biphasic Arc (also known as Arg3.1) elevations after fear experience and that the late Arc expression regu...

Accumulation of daily life stress (chronic stress) often causes functional gastrointestinal diseases. Central oxytocin plays an important role in attenuating stress responses and regulating positive social interactions. Adult male rats were either paired or singly housed 1 week prior to the stress loading. Solid gastric emptying was measured after 7 consecutive days of chronic heterotypic stres...

Abstract Background TERMINAL FLOWER 1 ( TFL1 ) belongs to the phosphatidylethanolamine-binding protein (PEBP) family, which is involved in inflorescence meristem development and represses flowering several plant species. In present study, four genes were cloned from mango Mangifera indica L.) variety ‘SiJiMi’ named MiTFL1-1 , MiTFL1-2 MiTFL1-3 MiTFL1-4 . Results Sequence analysis showed that en...

Delayed cell death by mitotic catastrophe is a frequent mode of solid tumor cell death after gamma-irradiation, a widely used treatment of cancer. Whereas the mechanisms that underlie the early gamma-irradiation-induced cell death are well documented, those that drive the delayed cell death are largely unknown. Here we show that the Fas, tumor necrosis factor-related apoptosis-inducing ligand (...

Decreased adhesion of neutrophils to endothelial cells and delayed transendothelial cell migration of neutrophils have been consistently reported in neonatal animals and humans and contribute to their susceptibility to infection. The delayed transmigration of neutrophils is especially prevalent in premature neonates. To define the nature of this defect, we used an in vivo animal model of inflam...

Abstract The chronic infection by Leishmania braziliensis causes a skin barrier (ulcer) breach and is susceptible to secondary bacterial infections. development of the ulcer associated with dysregulation microbiome, which we hypothesized impacts host gene expression, exacerbates inflammatory response, prolongs resolution disease. We conducted an integrative multi-omics meta-analysis clinical me...