hydrogel based metronidazole bioadhesive tablet (hmbt) was prepared as a novel vaginal delivery system to achieve controlled release of drug from the tablet for vaginal candidiasis. the highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by sem, dsc and ft-ir and evaluated for % ...

In plants, actin filaments have an important role in organelle movement and cytoplasmic streaming. Otherwise microtubules (MTs) have a role in restricting organelles to specific areas of the cell and in maintaining organelle morphology. In somatic plant cells, MTs also participate in cell division and morphogenesis, allowing cells to take their definitive shape in order to perform specific func...

An optimization strategy is described that combines high-fidelity simulations with response surface construction, and is applied to pulsed film cooling for turbine blades. The response surface is constructed for the film cooling effectiveness as a function of duty cycle, in the range of DC between 0.05 and 1, and pulsation frequency St in the range of 0.2–2, using a pseudospectral projection me...

Placenta ingestion has recently been shown to enhance opiate-mediated analgesia produced by morphine injection, footshock, or vaginal/cervical stimulation. The enhancement of the effect of endogenous opiates (especially analgesia) may be one of the principal benefits to mammalian mothers of placentophagia at delivery. During labor and delivery, however, mothers also ingest amniotic fluid (AF) w...

BACKGROUND Dysphagia occurs in up to 50% of patients admitted to hospital with acute strokes with up to 27% remaining by seven days. Up to 8% continue to have swallowing problems six months after their stroke with 1.7% still requiring enteral feeding. Nasogastric tubes (NGT) are the most commonly used method for providing enteral nutrition in early stroke, however they are easily and frequently...

BACKGROUND Anencephaly is a fatal congenital abnormality characterised by absence of cerebral hemisphere and cranial vault. Overall incidence of anencephaly is 3.8-6.0/1,000 births. This study was conducted to determine the prevalence, diagnosis and management of anencephaly in District Swat. METHODS This prospective study was carried out over a period of one year from January 2007 to Decembe...

Novel transducers are needed for point of care testing (POCT) devices which aim at facile, sensitive and quick acquisition of health related information. Recent advances in optofluidics offer tremendous opportunities for biological/chemical analysis using extremely small sample volumes. This paper demonstrates nanostructured capillary tubes for surface enhanced Raman spectroscopy (SERS) analysi...

BACKGROUND AND OBJECTIVES Bowel anastomosis after anterior resection is one of the most difficult tasks to perform during laparoscopic colorectal surgery. This study aims to evaluate a new feasible and safe intracorporeal anastomosis technique after laparoscopic left-sided colon or rectum resection in a pig model. METHODS The technique was evaluated in 5 pigs. The OrVil device (Covidien, Mans...

ENTERAL nutrition is the preferred route for providing nutrition support when the gastrointestinal (GI) tract is functional. Compared with conventional central venous feeding, enteral feeding is associated with fewer serious complications, is more nutritionally complete, is more effective in maintaining or restoring host immune response, and takes advantage of normal physiologic and metabolic p...