نتایج جستجو برای: dendritic cell dc

تعداد نتایج: 1753732  

2016
Veronica Rainone Cristina Martelli Luisa Ottobrini Mara Biasin Manuela Borelli Giovanni Lucignani Daria Trabattoni Mario Clerici Natalia Lapteva

INTRODUCTION Dendritic cells play a key role as initiators of T-cell responses, and even if tumour antigen-loaded dendritic cells can induce anti-tumour responses, their efficacy has been questioned, suggesting a need to enhance immunization strategies. MATHERIALS & METHODS We focused on the characterization of bone marrow-derived dendritic cells pulsed with whole tumour lysate (TAA-DC), as a...

2010
Daniel O. Ochiel Christina Ochsenbauer John C. Kappes Mimi Ghosh John V. Fahey Charles R. Wira

BACKGROUND Sexual transmission accounts for the majority of HIV-1 infections. In over 75% of cases, infection is initiated by a single variant (transmitted/founder virus). However, the determinants of virus selection during transmission are unknown. Host cell-cell interactions in the mucosa may be critical in regulating susceptibility to infection. We hypothesized in this study that specific im...

2006
Holger Hackstein

Dendritic cells (DC) are uniquely well-equipped antigen (Ag) presenting cells that initiate and regulate immune responses. DC play a dualistic role in the regulation of immune responses. They initiate adaptive immunity by the activating naive lymphocytes and are powerful stimulators of natural killer cells – the crucial cellular instigators of the innate immune system. Furthermore, DC induce ce...

Journal: :Journal of immunology 1999
N Kohrgruber N Halanek M Gröger D Winter K Rappersberger M Schmitt-Egenolf G Stingl D Maurer

Two types of dendritic cells (DC) are circulating in human blood and can be identified by their differential expression of the myeloid Ag CD11c. In this study, we show that CD11c- peripheral blood (PB)-DC correspond to plasmacytoid DC of lymphoid tissue not only by their surface Ag expression profile but, more impressively, by their peculiar ultramorphology. We also demonstrate that CD11c- and ...

Journal: :Cell reports 2016
Samuele Calabro Dong Liu Antonia Gallman Manuela Sales L Nascimento Zizi Yu Ting-Ting Zhang Pei Chen Biyan Zhang Lan Xu Uthaman Gowthaman Jayendra Kumar Krishnaswamy Ann M Haberman Adam Williams Stephanie C Eisenbarth

Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC subsets can activate both T cell lineages in vitro. Therefore, we tested whether the organization of DC and T cell subsets in the spleen dictated this preference. We discovered that CD4+ and ...

2016
Jinmiao Chen Andreas Schlitzer Svetoslav Chakarov Florent Ginhoux Michael Poidinger

Single-cell RNA-sequencing offers unprecedented resolution of the continuum of state transition during cell differentiation and development. However, tools for constructing multi-branching cell lineages from single-cell data are limited. Here we present Mpath, an algorithm that derives multi-branching developmental trajectories using neighborhood-based cell state transitions. Applied to mouse c...

Journal: :Immunology 2015
Lesley A Smyth Dominic A Boardman Sim L Tung Robert Lechler Giovanna Lombardi

MicroRNA (miRNA) are small, non-coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T-cell and B-cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNA in dendritic cell (DC) development as well as their maturation process, antigen ...

Journal: :The Journal of Experimental Medicine 1997
Bertrand Dubois Béatrice Vanbervliet Jérome Fayette Catherine Massacrier Cees Van Kooten Francine Brière Jacques Banchereau Christophe Caux

After antigen capture, dendritic cells (DC) migrate into T cell-rich areas of secondary lymphoid organs, where they induce T cell activation, that subsequently drives B cell activation. Here, we investigate whether DC, generated in vitro, can directly modulate B cell responses, using CD40L-transfected L cells as surrogate activated T cells. DC, through the production of soluble mediators, stimu...

Journal: :Developmental and comparative immunology 2010
Zhiguang Wu Tuanjun Hu Colin Butter Pete Kaiser

A cDNA encoding the chicken orthologue of dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208 was cloned by RT-PCR from RNA isolated from mature chicken bone marrow-derived dendritic cells (chBM-DCs). The cloned chicken DC-LAMP (chDC-LAMP) cDNA consists of 1281 nucleotides encoding an open reading frame of 426 amino acids (aa). Comparison of the deduced aa sequence of DC-LAMP w...

2002
Loc T. Nguyen Suresh Radhakrishnan Bogoljub Ciric Koji Tamada Tahiro Shin Drew M. Pardoll Lieping Chen Moses Rodriguez Larry R. Pease

B7-DC molecules are known to function as ligands on antigen-presenting cells (APCs), enhancing T cell activation. In this study, cross-linking B7-DC with the monoclonal antibody sHIgM12 directly potentiates dendritic cell (DC) function by enhancing DC presentation of major histocompatibility complex-peptide complexes, promoting DC survival; and increasing secretion of interleukin (IL)-12p70, a ...

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