The aim of this work was to evaluate the lipid profile Plasmodium berghei infected rats treated with aqueous extract Cassia spectabilis. Twenty five (25) adult male wistar were divided into (5) groups per group. Group I normal control fed only rat chow and water, II parasite without treatment. Groups III IV afterwards 200 mg/kg 400 spectabilis respectively, while V a standard drug (chloroquine)...

Background: Ventoluft Polyherbal formulation composes multiple traditional medicinal plants composed of various anti-inflammatory agents. Hence, the present study aimed to investigate effect on Freund’s complete adjuvant-induced arthritic male Wistar rats. Materials and methods: The included thirty-six rats, containing six in each. Arthritis was induced by injecting FCA (0.1ml) joints right sub...

In patients with type 2 diabetes mellitus (T2DM), both innate and acquired immunity are weakened by hyperglycemia. Lycopene is one of the hydrocarbon carotenoids that has been widely studied for its powerful antioxidant anti-inflammatory properties, furthermore act as hypoglycemic immunomodulator. Herein, we investigated effect lycopene metformin combination on fasting blood glucose (FBG) neutr...

Background : Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity of C. odorata leaves extract in DMBA induced breast on rats. Methods Seven groups Rattus novergicus were used: Four treatment (500, 1000, 2000, and 4000 mg/kg BW), normal control, group. The number, volume, weight nodule rats’...

We have reported that extent of proliferation atypical hepatocytes (POAH) in non-cancerous liver hepatocellular carcinoma and chromatin licensing DNA replication factor 1 (CDT1) are associated with postoperative recurrence. Here, we investigated whether POAH expression CDT1 also chemically induced cancer rats. Male Fisher strain rats were orally administered diethylnitrosamine (DEN) their drink...

Objective(s) Studies have shown that morphine, in addition to its analgesic properties, has several effects on cell proliferation and apoptosis. There is also evidence that opioid receptors are present on chondrocytes. Our main objective in the present study was to investigate the effects of morphine on rat femur growth cartilage. Materials and Methods This research was carried out on 18 4-we...

BACKGROUND Very limited information has been published regarding cardiac apoptosis in menopausal women or in those after bilateral oophorectomy. The purpose of this study was to evaluate whether cardiac Fas-dependent (type I) and mitochondria-dependent (type II) apoptotic pathways are activated in ovariectomized rats. METHODS Thirty-two female Wistar rats at 6-7 months of age were randomly di...

Endogenous opioid system agonists exert amnestic effects in different models of memory. It has been suggested that these amnestic effects may be linked indirectly to state-dependent learning. Accordingly pre-training administration of morphine can impair the retrieval of learned tasks in a state dependent manner, which is reversible by pre test morphine administration. In this study, state depe...

Endogenous opioid system agonists exert amnestic effects in different models of memory. It has been suggested that these amnestic effects may be linked indirectly to state-dependent learning. Accordingly pre-training administration of morphine can impair the retrieval of learned tasks in a state dependent manner, which is reversible by pre test morphine administration. In this study, state depe...